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Titolo:
Cerebral maturation in premature infants: Quantitative assessment using MRimaging
Autore:
Childs, AM; Ramenghi, LA; Cornette, L; Tanner, SF; Arthur, RJ; Martinez, D; Levene, MI;
Indirizzi:
Leeds Gen Infirm, Dept Paediat Radiol, Leeds, W Yorkshire, England Leeds Gen Infirm Leeds W Yorkshire England , Leeds, W Yorkshire, England Univ Leeds, Div Paediat, Leeds LS2 9JT, W Yorkshire, England Univ Leeds Leeds W Yorkshire England LS2 9JT S2 9JT, W Yorkshire, England Univ Leeds, Dept Med Phys, Leeds LS2 9JT, W Yorkshire, England Univ LeedsLeeds W Yorkshire England LS2 9JT S2 9JT, W Yorkshire, England Univ Leeds, Ctr Med Imaging Res, Leeds LS2 9JT, W Yorkshire, England Univ Leeds Leeds W Yorkshire England LS2 9JT S2 9JT, W Yorkshire, England
Titolo Testata:
AMERICAN JOURNAL OF NEURORADIOLOGY
fascicolo: 8, volume: 22, anno: 2001,
pagine: 1577 - 1582
SICI:
0195-6108(200109)22:8<1577:CMIPIQ>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXTREMELY PRETERM INFANTS; WHITE-MATTER; EARLY MYELINATION; BRAIN-DEVELOPMENT; NEONATAL BRAIN; FEATURES; NEWBORNS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Childs, AM Leeds Gen Infirm, Div Paediat, D Floor,Clarendon Wing,Belmont Grove, LeedsLS2 9NS, W Yorkshire, England Leeds Gen Infirm D Floor,ClarendonWing,Belmont Grove Leeds W Yorkshire England LS2 9NS
Citazione:
A.M. Childs et al., "Cerebral maturation in premature infants: Quantitative assessment using MRimaging", AM J NEUROR, 22(8), 2001, pp. 1577-1582

Abstract

BACKGROUND AND PURPOSE: The assessment of whether brain development is at an appropriate level for age has become an integral part of clinical MR reporting, although few studies have quantitatively defined the developmental changes occurring in premature infants. We have developed a simple scoring system to assess four parameters of cerebral maturation-myelination, cortical folding, glial cell migration, and germinal matrix distribution-to determine the total maturation score (TMS). The aim of this study was to validate this scoring system in a large population of preterm infants across a range of gestational ages. METHODS: A retrospective analysis was conducted of MR images acquired overa 3-year period with an identical imaging protocol. Infants born more than14 days before the imaging examination and those with a clinical or radiologic history suggestive of neuroabnormality were excluded from the study. The TMS was derived by consensus. Interobserver agreement was evaluated by using the Bland-Altman plot. RESULTS: Images from 134 infants (23-41 weeks' gestational age) were evaluated. The TMS was significantly related to the postmenstrual age of the infant, with the mean TMS for each age group increasing with advancing postmenstrual age. Interobserver agreement was found to be high (mean difference in score = 0.07, SD = 0.56). CONCLUSION: This scoring system provides a standardized method for assessing cerebral maturation in the premature infant. The TMS is easy to calculate from standard MR images, is reproducible, and can help detect changes occurring within a postnatal age of a few weeks.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 07:26:14