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Titolo:
Visualization of nonstructural changes in early white matter development on diffusion-weighted MR images: evidence supporting premyelination anisotropy
Autore:
Prayer, D; Barkovich, AJ; Kirschner, DA; Prayer, LM; Roberts, TPL; Kucharczyk, J; Moseley, ME;
Indirizzi:
Univ Calif San Francisco, Dept Radiol, Neuroradiol Sect, San Francisco, CA94143 USA Univ Calif San Francisco San Francisco CA USA 94143 rancisco, CA94143 USA Univ Vienna, Neuroradiol Sect, Dept Radiol, A-1010 Vienna, Austria Univ Vienna Vienna Austria A-1010 t, Dept Radiol, A-1010 Vienna, Austria Boston Coll, Dept Biol, Chestnut Hill, MA 02167 USA Boston Coll Chestnut Hill MA USA 02167 Biol, Chestnut Hill, MA 02167 USA Stanford Univ, Dept Radiol, Palo Alto, CA 94304 USA Stanford Univ Palo Alto CA USA 94304 Dept Radiol, Palo Alto, CA 94304 USA
Titolo Testata:
AMERICAN JOURNAL OF NEURORADIOLOGY
fascicolo: 8, volume: 22, anno: 2001,
pagine: 1572 - 1576
SICI:
0195-6108(200109)22:8<1572:VONCIE>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT OPTIC-NERVE; MULTIPLE-SCLEROSIS; WATER DIFFUSION; AXONS; BRAIN; CNS; ANTIBODIES; CHANNELS; LESIONS; SYSTEM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Roberts, TPL Univ Calif San Francisco, Dept Radiol, Neuroradiol Sect, Box 0628,513 Parnassus Ave, San Francisco, CA 94143 USA Univ Calif San Francisco Box 0628,513 Parnassus Ave San Francisco CA USA 94143
Citazione:
D. Prayer et al., "Visualization of nonstructural changes in early white matter development on diffusion-weighted MR images: evidence supporting premyelination anisotropy", AM J NEUROR, 22(8), 2001, pp. 1572-1576

Abstract

BACKGROUND AND PURPOSE: Previously, we showed that diffusion-weighted MR imaging depicts evidence of directionally preferential water motion in whitematter structures of developing rat brain before and after myelination, and considerably earlier than conventional imaging strategies. Present data augment these imaging and corresponding histologic findings with electron-microscopic corroboration. We additionally report the findings of a 10-day-old rat pup tested functionally by administration of the sodium-channel blocker, tetrodotoxin. METHODS: In two rat pups, drawn from the population reported previously, MR estimates of diffusion anisotropy of the optic nerves and chiasm were compared with histologic and electron microscopy results. To test the hypothesis that "premyelination" directional preference of water motion in white matter structures relates to sodium-channel activity, MR imaging was performed in a 10-day-old rat pup treated with the sodium-channel blocker, tetrodotoxin, and findings were compared with data from an age-matched control. RESULTS: Although diffusion anisotropy was present in optic structures of the youngest animal, myelin-sensitive histologic staining did not show myelin before 12 days; electron microscopy confirmed lack of any myelin or its precursors during the earliest maturational stage. Administration of tetrodotoxin to the 10-day-old rat-pup led to loss of diffusion anisotropy. CONCLUSION: Our findings provide two pieces of supporting data for the hypothesis that nonstructural changes are responsible for early anisotropic diffusion: electron microscopy shows no evidence of myelin despite diffusion anisotropy, and inhibiting the sodium-channel pump appears to remove the directional preference of water motion. Visualization of nonstructural "premyelination" consequences with diffusion-weighted imaging emphasizes its sensitivity and potential in studying early processes of brain development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 19:30:26