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Titolo:
MR imaging and single-photon emission CT findings after gene therapy for human glioblastoma
Autore:
Floeth, FW; Aulich, A; Langen, KJ; Burger, KJ; Bock, WJ; Weber, F;
Indirizzi:
Univ Dusseldorf, Dept Neurosurg, D-40225 Dusseldorf, Germany Univ Dusseldorf Dusseldorf Germany D-40225 , D-40225 Dusseldorf, Germany Univ Dusseldorf, Dept Diagnost Radiol, D-4000 Dusseldorf, Germany Univ Dusseldorf Dusseldorf Germany D-4000 ol, D-4000 Dusseldorf, Germany KFA Julich GmbH, Res Ctr, Inst Med, D-5170 Julich, Germany KFA Julich GmbH Julich Germany D-5170 , Inst Med, D-5170 Julich, Germany Novartis Pharma GmbH, Nurnberg, Germany Novartis Pharma GmbH Nurnberg Germany is Pharma GmbH, Nurnberg, Germany
Titolo Testata:
AMERICAN JOURNAL OF NEURORADIOLOGY
fascicolo: 8, volume: 22, anno: 2001,
pagine: 1517 - 1527
SICI:
0195-6108(200109)22:8<1517:MIASEC>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE SPECTROSCOPY; ALPHA-METHYL-TYROSINE; HUMAN BRAIN-TUMORS; MALIGNANT GLIOMA; ABSOLUTE CONCENTRATIONS; RECURRENT GLIOBLASTOMA; CEREBRAL GLIOMAS; RESECTION; SURVIVAL; PET;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Floeth, FW Univ Dusseldorf, Dept Neurosurg, Moorenstr 5, D-40225 Dusseldorf, Germany Univ Dusseldorf Moorenstr 5 Dusseldorf Germany D-40225 Germany
Citazione:
F.W. Floeth et al., "MR imaging and single-photon emission CT findings after gene therapy for human glioblastoma", AM J NEUROR, 22(8), 2001, pp. 1517-1527

Abstract

BACKGROUND AND PURPOSE: Our goal was to evaluate MR imaging findings afterlocal intracerebral gene therapy in patients with glioblastoma and differentiate postoperative contrast enhancement phenomena. METHODS: In all, 26 patients with supratentorial single lesion glioblastoma underwent tumor resection and intracerebral injection of murine retroviral vector-producer cells for gene therapy with the herpes simplex virus typeI thymidine kinase gene/ganciclovir system. Serial contrast-enhanced MR studies were obtained before treatment and postoperatively on day I or 2; weeks 2, 4, 9, 13, 17, 25, and 33; and every 8 weeks thereafter. Iodomethyltyrosine single-photon emission CT (IMT-SPECT) investigations also were performed in selected cases. RESULTS: Twelve patients showed nontumorous enhancement of various intensities after treatment, arising within 18 to 72 hours and persisting at 3 to 10 months. It was characterized by a strong local enhancement up to 20 mm thick, which was initially nodular and later linear along the resection cavity wall and surrounded by massive perifocal edema. This "flare" enhancementhad features that clearly differed from those of residual tumor enhancements and benign postsurgical enhancements. The IMT-SPECT investigations showed increased amino acid uptake in patients with enhancement from residual orrelapsing tumor, but not in patients with flare. CONCLUSION: After local gene therapy, a unique dynamic, transient perifocal flare enhancement can occur on MR images. IMT-SPECT may help to differentiate between tumorous and nontumorous flare enhancements in patients with enhancing tissue on MR images after gene therapy for glioblastoma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/21 alle ore 17:45:16