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Titolo:
Nasal vaccines
Autore:
Davis, SS;
Indirizzi:
Univ Nottingham, Inst Pharmaceut Sci, Nottingham NG7 2RD, England Univ Nottingham Nottingham England NG7 2RD , Nottingham NG7 2RD, England
Titolo Testata:
ADVANCED DRUG DELIVERY REVIEWS
fascicolo: 1-3, volume: 51, anno: 2001,
pagine: 21 - 42
SICI:
0169-409X(20010923)51:1-3<21:NV>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY SYNCYTIAL VIRUS; MUCOSAL IMMUNE-RESPONSES; HERPES-SIMPLEX VIRUS; RECOMBINANT BORDETELLA-PERTUSSIS; SYSTEMIC ANTIBODY-RESPONSES; MEMBRANE VESICLE VACCINE; HEAT-LABILE ENTEROTOXIN; T-CELL RESPONSES; TOXIN-B-SUBUNIT; NASOPHARYNGEAL LYMPHOID-TISSUE;
Keywords:
nasal vaccines; nose-associated lymphoid tissue; Waldeyer's ring; tonsils; common mucosal immune system;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
165
Recensione:
Indirizzi per estratti:
Indirizzo: Davis, SS Univ Nottingham, Inst Pharmaceut Sci, Boots Sci Bldg,Sci Rd,UnivPk, Nottingham NG7 2RD, England Univ Nottingham Boots Sci Bldg,Sci Rd,UnivPk Nottingham England NG7 2RD
Citazione:
S.S. Davis, "Nasal vaccines", ADV DRUG DE, 51(1-3), 2001, pp. 21-42

Abstract

The nasal route for vaccination offers some important opportunities, especially for the prophylaxis of respiratory diseases. Vaccination via the respiratory tract is reviewed and the deposition and clearance of antigens in the deep lung and nose are described and contrasted. Lymphoid structures in the respiratory tract differ according to species; the rat and mouse have awell developed nose-associated lymphoid tissue, while in man, the structure known as Waldeyer's ring (that includes the tonsils), is important as an induction site. The immune response following intranasal administration canprovide protection at the administration site and at various effector sites as part of the common mucosal immune system. A number of formulation considerations are important when designing novel systems for nasal administration as are physiological factors such as mucociliary clearance. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 18:29:46