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Titolo:
Alcohol dehydrogenase ADH2-1 and ADH2-2 allelic isoforms in the Russian population correlate with type of alcoholic disease
Autore:
Ogurtsov, PP; Garmash, IV; Miandina, GI; Guschin, AE; Itkes, AV; Moiseev, VS;
Indirizzi:
Res Inst Addict, Dept Toxicol, Moscow 113628, Russia Res Inst Addict Moscow Russia 113628 Dept Toxicol, Moscow 113628, Russia Peoples Friendship Univ Russia, Sch Med, Moscow, Russia Peoples FriendshipUniv Russia Moscow Russia a, Sch Med, Moscow, Russia Minist Publ Hlth Russia, Cent Res Inst Epidemiol, Moscow, Russia Minist Publ Hlth Russia Moscow Russia es Inst Epidemiol, Moscow, Russia
Titolo Testata:
ADDICTION BIOLOGY
fascicolo: 4, volume: 6, anno: 2001,
pagine: 377 - 383
SICI:
1355-6215(200109)6:4<377:ADAAAA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIVER-DISEASE; ADH2-ASTERISK-2 ALLELE; DRINKING; GENOTYPES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Ogurtsov, PP Res Inst Addict, Dept Toxicol, Kulikovskaya Ul 3-51, Moscow 113628, Russia Res Inst Addict Kulikovskaya Ul 3-51 Moscow Russia 113628 ia
Citazione:
P.P. Ogurtsov et al., "Alcohol dehydrogenase ADH2-1 and ADH2-2 allelic isoforms in the Russian population correlate with type of alcoholic disease", ADDICT BIOL, 6(4), 2001, pp. 377-383

Abstract

The frequency ADH2-2 allele in the Moscow urban population and a cor relation between the ADH2-2 allele, alcoholic dependence without cirrhosis, symptomatic alcoholic cirrhosis and status on hepatitis B and C infection have been studied. One hundred and twenty-three inhabitants of Moscow (50 healthy donors, 36 patients with alcoholic cirrhosis (subdivided into infected and uninfected by HBV and/or HCV) and 37 patients with alcoholic dependence) of a similar age/sex and drinking pattern have been analysed. The frequencyof 41% for ADH2-2 allele is characteristic for an urban Moscow population. This value is intermediate between that found for Asian peoples and for Central and Western Europe. There is a negative cor relation between the ADH2-2 allele and alcohol misuse (both alcoholic dependence and alcoholic cirrhosis). This correlation is expressed more in alcoholic dependence. In spiteof the possession of the ADH2-2 allele (or genotype ADH2-1/2), alcohol misuse increases the risk of cirrhosis. At the same time, positive status for active hepatitis B, C or combined infection B + C (replication markers HBV-DNA or HCV-RNA) increases the risk for symptomatic alcoholic cirrhosis in alcohol abusing patients, independently of ADH2 genotype.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 09:12:04