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Titolo:
A putative sigma(1) receptor antagonist NE-100 attenuates the discriminative stimulus effects of ketamine in rats
Autore:
Narita, M; Yoshizawa, K; Aoki, K; Takagi, M; Miyatake, M; Suzuki, T;
Indirizzi:
Hoshi Univ, Sch Pharm, Dept Toxicol, Shinagawa Ku, Tokyo 1428501, Japan Hoshi Univ Tokyo Japan 1428501 xicol, Shinagawa Ku, Tokyo 1428501, Japan
Titolo Testata:
ADDICTION BIOLOGY
fascicolo: 4, volume: 6, anno: 2001,
pagine: 373 - 376
SICI:
1355-6215(200109)6:4<373:APSRAN>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
BINDING-SITES; PHENCYCLIDINE; BRAIN; LIGAND; HUMANS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Suzuki, T Hoshi Univ, Sch Pharm, Dept Toxicol, Shinagawa Ku, 2-4-41 Ebara,Tokyo 1428501, Japan Hoshi Univ 2-4-41 Ebara Tokyo Japan 1428501 okyo 1428501, Japan
Citazione:
M. Narita et al., "A putative sigma(1) receptor antagonist NE-100 attenuates the discriminative stimulus effects of ketamine in rats", ADDICT BIOL, 6(4), 2001, pp. 373-376

Abstract

Ketamine, one of the dissociative anaesthetic agents, has been shown to produce psychotomimetic effects. It has been well documented that activation of sigma receptors is responsible for the pathogenesis of some psychiatric disorders. In the present study, the effects of NE-100, a putative sigma(1)receptor antagonist, was investigated in rats trained to discriminate between ketamine (5 mg/kg, i.p.) from saline under a fixed-ratio 10 food-reinforced procedure. Here we report for the first time that NE-100 (1 mg/kg) produced a shift to the right in the dose-response curve for ketamine's discriminative stimulus effects. These results suggest that the sigma1 receptor is, at least in part, involved in the discriminative stimulus effects of ketamine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 11:25:40