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Titolo:
Serotonin transporter (5-HTT) gene polymorphisms and susceptibility to cocaine dependence among African-American individuals
Autore:
Patkar, AA; Berrettini, WH; Hoehe, M; Hill, KP; Sterling, RC; Gottheil, E; Weinstein, SP;
Indirizzi:
Thomas Jefferson Univ, Dept Psychiat & Human Behav, Div Subst Abuse Programs, Philadelphia, PA 19107 USA Thomas Jefferson Univ Philadelphia PA USA 19107 hiladelphia, PA 19107 USA Univ Penn, Dept Psychiat, Ctr Neurobiol & Behav, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 l & Behav, Philadelphia, PA 19104 USA Max Delbruck Ctr Mol Med, Berlin, Germany Max Delbruck Ctr Mol Med Berlin Germany ck Ctr Mol Med, Berlin, Germany
Titolo Testata:
ADDICTION BIOLOGY
fascicolo: 4, volume: 6, anno: 2001,
pagine: 337 - 345
SICI:
1355-6215(200109)6:4<337:ST(GPA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
D2 RECEPTOR GENE; SUBSTANCE-ABUSE; HUMAN-BRAIN; DISCRIMINATIVE STIMULUS; FAMILIAL TRANSMISSION; INTRAVENOUS COCAINE; DRUG-ABUSE; DOPAMINE; ASSOCIATION; ALCOHOLISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Patkar, AA Thomas Jefferson Univ, Dept Psychiat & Human Behav, Div Subst Abuse Programs, 833 Chestnut St E,Suite 210E, Philadelphia, PA 19107 USA Thomas Jefferson Univ 833 Chestnut St E,Suite 210E Philadelphia PA USA 19107
Citazione:
A.A. Patkar et al., "Serotonin transporter (5-HTT) gene polymorphisms and susceptibility to cocaine dependence among African-American individuals", ADDICT BIOL, 6(4), 2001, pp. 337-345

Abstract

Studies indicate that the serotonin system, particularly the serotonin transporter (5-HTT), may modulate the central effects of cocaine. We investigated whether a polymorphism in the 5' promotor region (5-HTTLPR) of the 5-HTT gene confers susceptibility to cocaine dependence. One hundred and ninety-seven cocaine-dependent African-American subjects and 101 controls were studied. Polymerase chain reaction based genotyping of a biallelic repeat polymorphism in the 5' promotor region yielded 2 alleles containing 484 (S) and 528 bp (L) repeats, respectively. There were no significant differences between controls of European background (n=40) and African-American controls(n=61) in distribution of genotypes (European: LL=32.5%, LS=40.0%, SS=27.5%; African-American: LL=27.9%, LS=57.4%, SS=14.7%) (chi (2)=3.60, df=2, p=0.16) or allele frequencies (European: L=52.5%, S=47.5%; African-American: L=56.6%, S=43.4%) (chi (2)=2.21, df=1, p=0.13). When cocaine patients were compared to an ethnically diverse control group (n=101), frequencies of the L variant (65.0%) were significantly higher while the S variant (35.0%) wasless frequent among cocaine patients compared to controls (L=53.9%, S=46.1%) (chi (2)=6.83, df=1, p<0.01). Similarly, there were more cocaine patients with the LL genotype (41.1%) and less with the SS genotype (11.2%) compared to controls (LL=29.7%, SS=21.8%) (<chi>(2)=7.43, df=2, p<0.05). However,after restricting controls to African-American individuals only (n=61), cocaine subjects and controls did not differ significantly with respect to genotype distribution (<chi>(2)=4.24, df=2, p=0.12) or allele frequencies (chi (2)=2.83, df=1, p=0.10). In conclusion, although comparisons with a heterogeneous control group indicated a possible association between allelic variants of 5-HTTLPR and cocaine dependence among African-American cocaine subjects, this relationship was not observed when the control group was limited to African-American people only. Our findings need to be confirmed on larger samples of ethnically matched individuals.

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Documento generato il 23/01/20 alle ore 12:44:36