Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Polymorphisms at the DRD2 locus in early-onset alcohol dependence in the Indian population
Autore:
Shaikh, KJ; Naveen, D; Sherrin, T; Murthy, A; Thennarasu, K; Anand, A; Benegal, V; Jain, S;
Indirizzi:
Natl Inst Mental Hlth & Neurosci, Deaddict Ctr, Bangalore 560029, Karnataka, India Natl Inst Mental Hlth & Neurosci Bangalore Karnataka India 560029, India Jawaharlal Nehru Inst Adv Sci Res, Bangalore, Karnataka, India Jawaharlal Nehru Inst Adv Sci Res Bangalore Karnataka India ataka, India
Titolo Testata:
ADDICTION BIOLOGY
fascicolo: 4, volume: 6, anno: 2001,
pagine: 331 - 335
SICI:
1355-6215(200109)6:4<331:PATDLI>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
D2 RECEPTOR GENE; NO ASSOCIATION; AL ALLELE; ENVIRONMENTAL CONTRIBUTIONS; A1 ALLELE; LINKAGE; RISK; FREQUENCIES; DRINKING; TAIWAN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Benegal, V Natl Inst Mental Hlth & Neurosci, Deaddict Ctr, Bangalore 560029, Karnataka, India Natl Inst Mental Hlth & Neurosci Bangalore Karnataka India 560029
Citazione:
K.J. Shaikh et al., "Polymorphisms at the DRD2 locus in early-onset alcohol dependence in the Indian population", ADDICT BIOL, 6(4), 2001, pp. 331-335

Abstract

The susceptibility to alcohol dependence is probably of polygenic origin. Association studies have attempted to identify possible candidate genes that may contribute to the risk to developing dependence. Severe for ms of thealcoholism phenotype have been associated with an increased frequency of the Taq A1 allele at the DRD2 locus. Ethnic stratification and non-comparable phenotype may have contributed to the contradictory results in previous studies. We identified probands, using the Schedules of Assessment of Neuropsychiatry (SCAN) schedule, who had onset of alcohol dependence (ICD-10) before 25 years of age. Family members were inter viewed using the Family Inter view for Genetic Studies (FIGS) schedule to identify patients who had twofirst-degree relatives with alcohol dependence. Fifty subjects who fulfilled the criteria were selected for the study. These were compared to a nor mal population from a similar background. The allele frequencies did not differ between the two groups. The Taq1a polymorphism does not seem to be associated with alcoholism in this group of severely affected, young age of onset probands in the southern Indian population.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 20:04:12