Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effect of quercetin on adhesion of platelets to microvascular endothelial cells in vitro
Autore:
Fan, PS; Gu, ZL; Liang, ZQ;
Indirizzi:
Suzhou Univ, Suzhou Inst Chinese Mat Med, Dept Pharmacol, Suzhou 215007, Peoples R China Suzhou Univ Suzhou Peoples R China 215007 Suzhou 215007, Peoples R China
Titolo Testata:
ACTA PHARMACOLOGICA SINICA
fascicolo: 9, volume: 22, anno: 2001,
pagine: 857 - 860
SICI:
0253-9756(200109)22:9<857:EOQOAO>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
REPERFUSION;
Keywords:
vascular endothelium; quercetin; adhesions; enzyme-linked immunosorbent assay; blood platelets;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
9
Recensione:
Indirizzi per estratti:
Indirizzo: Gu, ZL Suzhou Univ, Suzhou Inst Chinese Mat Med, Dept Pharmacol, Suzhou 215007, Peoples R China Suzhou Univ Suzhou Peoples R China 215007 215007, Peoples R China
Citazione:
P.S. Fan et al., "Effect of quercetin on adhesion of platelets to microvascular endothelial cells in vitro", ACT PHAR SI, 22(9), 2001, pp. 857-860

Abstract

AIM: To study the effect of quercetin(Que) on the adhesion of platelets tomicrovascular endothelial cells (MVEC) isolated from human skin. METHODS: [H-3]-adenine-labeled platelets were incubated with MVEC. Effect of Que on platelet endothelial cell adhesion molecular (PECAM) expression on NIVEC was also evaluated using enzyme-linked immunosorbent assay (ELISA). RESULTS: Adhesion of platelet to MVEC reached to maximum at about 30 min. Que inhibited the adhesion of platelets to MVEC in a concentration-dependent manner. Que 5 mu mol/L did not show any significant inhibition. When the concentration of Que increased to 10, 20, and 40 mu mol/L, the inhibition rate increased to 10.5 %, 20.0 %, and 42.2 %, respectively. Pre-incubation of Que (10 - 40 mu mol/L) with labeled platelets for 30 min also inhibited the adhesion ut Que 5 mu mol/L did not. The inhibition rate of Que 10, 20, and 40 mu mol/L was 18.2 %, 29.8 %, and 65.3 % respectively. Expression of PECAM on the endothelial cells was decreased in a concentration-dependent manner when MVEC were treated with Que (10 - 40 mu mol/L) for 12 h but Que 5 mu mol/L did not significantly affect the expression. CONCLUSION: Que could inhibit the adhesion of platelets to MVEC. This effect may be related to decreased expression of PECAM on MVEC.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 16:02:17