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Titolo:
Manganese intake and cholestatic jaundice in neonates receiving parenteralnutrition: a randomized controlled study
Autore:
Fok, TF; Chui, KKM; Cheung, R; Ng, PC; Cheung, KL; Hjelm, M;
Indirizzi:
Chinese Univ Hong Kong, Prince Wales Hosp, Dept Paediat, Shatin, Hong Kong, Peoples R China Chinese Univ Hong Kong Shatin Hong Kong Peoples R China Peoples R China Chinese Univ Hong Kong, Prince Wales Hosp, Dept Chem Pathol, Shatin, Hong Kong, Peoples R China Chinese Univ Hong Kong Shatin Hong Kong Peoples R China Peoples R China
Titolo Testata:
ACTA PAEDIATRICA
fascicolo: 9, volume: 90, anno: 2001,
pagine: 1009 - 1015
SICI:
0803-5253(200109)90:9<1009:MIACJI>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
BILIRUBIN-INDUCED CHOLESTASIS; CHRONIC LIVER-DISEASE; PREMATURE-INFANTS; CHRONIC EXPOSURE; FUNGICIDE MANEB; NEWBORN-INFANTS; PARKINSONISM; TOXICITY; INTOXICATION; INFECTION;
Keywords:
cholestasis; direct bilirubin; manganese; neonates; parenteral nutrition;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Fok, TF Chinese Univ Hong Kong, Prince Wales Hosp, Dept Paediat, Shatin, Hong Kong, Peoples R China Chinese Univ Hong Kong Shatin Hong Kong Peoples R China R China
Citazione:
T.F. Fok et al., "Manganese intake and cholestatic jaundice in neonates receiving parenteralnutrition: a randomized controlled study", ACT PAEDIAT, 90(9), 2001, pp. 1009-1015

Abstract

Infants requiring parenteral nutrition (n = 244) were randomized to receive either 1 (group 1, n = 121) or 0.0182 mu mol/kg/d (group 2, n = 123) of manganese supplementation. The whole-blood manganese and serum direct bilirubin concentrations of the infants were monitored, as was the development ofcholestasis (peak serum direct bilirubin concentration > 50 mu mol/L). Subgroup analysis was carried out on the data of 78 infants in group I and 82 in group 2 who had received manganese supplementation and more than three-quarters of their total daily fluid as parenteral nutrition for > 14 d. Of all the infants randomized, the high manganese group (group 1) showed a trend towards developing higher peak whole-blood manganese concentration [groupI versus group 2: median (interquartile range): 606.0 (421.0; 1005.0) vs 566.0 (336.0; 858.0); p=0.061] and higher peak serum direct bilirubin concentration [37.0 (10.5; 122.5) vs 19.0 (8.0, 112.5); p = 0.153], but the differences between the 2 groups did not reach statistical significance. The 2 groups did not differ in terms of the occurrence of cholestasis during parenteral nutrition (63/121 vs 57/123; P = 0.444). Subgroup analysis of infantswho had received more than three-quarters of their total daily fluid as parenteral nutrition showed, however, that the high manganese group developedsignificantly higher whole-blood manganese concentration [743.5 (498.0; 1211.0) vs 587.0 (438.0; 982.0); p = 0.037] and serum direct bilirubin concentration [84.0 (28.0; 170.0) vs 25.5 (9.0; 117.0); p < 0.001]. Although there was no significant difference in the occurrence of cholestasis (58/78 vs 49/82; p = 0.073), more infants in the high manganese group developed a more severe degree of direct hyperbilirubinaemia, with peak serum direct bilirubin > 100 mu mol/L (32/78 vs 20/82; p = 0.038). Conclusion: We conclude that the pathogenesis of parenteral nutrition-related cholestasis is probably multifactorial, and that high manganese intake is a significant contributory factor.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/06/19 alle ore 17:01:35