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Titolo:
Serum uric acid for short-term prediction of cardiovascular disease incidence in the Gubbio population Study
Autore:
Puddu, PE; Lanti, M; Menotti, A; Mancini, M; Zanchetti, A; Cirillo, M; Angeletti, M; Panarelli, W;
Indirizzi:
Assoc Ric Cardiol, I-00198 Rome, Italy Assoc Ric Cardiol Rome Italy I-00198 oc Ric Cardiol, I-00198 Rome, Italy
Titolo Testata:
ACTA CARDIOLOGICA
fascicolo: 4, volume: 56, anno: 2001,
pagine: 243 - 251
SICI:
0001-5385(200108)56:4<243:SUAFSP>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
SODIUM-LITHIUM COUNTERTRANSPORT; BLOOD-PRESSURE; FOLLOW-UP; RISK; HYPERTENSION; EVENTS; CHART;
Keywords:
cardiovascular disease; epidemiology; serum uric acid; risk factors; prediction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Puddu, PE Assoc Ric Cardiol, Via Adda 87, I-00198 Rome, Italy Assoc Ric Cardiol Via Adda 87 Rome Italy I-00198 98 Rome, Italy
Citazione:
P.E. Puddu et al., "Serum uric acid for short-term prediction of cardiovascular disease incidence in the Gubbio population Study", ACT CARDIOL, 56(4), 2001, pp. 243-251

Abstract

Objective - The Gubbio Study is an Italian population study measuring riskfactors for and incidence of major cardiovascular diseases.This analysis investigates the association of serum uric acid with the incidence of coronary and cardiovascular events. Methods - A population sample of 2469 men and women aged 35-74 years, freefrom major cardiovascular diseases and in whom serum uric acid was measured in 1983 along with other standard risk factors, were followed up for 6 years and the incidence of coronary heart disease (CND) and all cardiovascular atherosclerotic (CVD) events, both fatal and non-fatal, was computed. Proportional hazards models were used for the prediction of these events. Results - In six years 61 CHD hard criteria, 109 CHD any criterion and 149CVD events were recorded. Age-adjusted rates per 1000 of the 3 event categories were computed in sex-specific quintiles (Q) of serum uric acid with 428 +/- 76 (Q(5)) and 198 +/- 42 (Q(1)) mu mol/l, respectively. Although higher rates were seen in Q(5) as compared to Q(1) for all three first event categories considered (relative risks 6.2, 3.6 and 3.7, respectively), a statistically significant trend was seen only for CVD all criteria (t = 3.63, p < 0.036). These trends were borderline significant for CHD any criterion (t = 2.92, p < 0.06) and not significant for CHD hard criteria (t = 2.23, p< 0.11). In multivariate models, adjusted for 8 other risk factors, serum uric acid showed a statistically significant contribution to predict CVD incidence [relative risk (RR) for 92 mu mol/l difference of 1.24 with 95% confidence intervals (CI) 1.05-1.45], whereas the statistical contribution to predict CHD any criterion (RR = 1.19 with CI 0.98-1.45) and CHD hard criteria (RR = 1.20 with CI 0.93-1.55) was not significant. Diuretic treatment and blood urea, as further confounders, were positively and significantly related to event incidence (RR ranging from 1.21 to 2.00) but serum uric acid maintained its independent and statistically significant role in the prediction of CVD events (RR = 1.18 with CI 1.00-1.39). Presence of specific treatments to lower serum uric acid levels (in 1.13% of the population), testedas final confounders, was not statistically contributory. Conclusions - Increased serum uric acid levels are independently and significantly associated with risk of CVD events in the 6-year follow-up of the Gubbio Study. Longer follow-up is needed before the contributory role of serum uric acid can be properly assessed to explain CHD incidence.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 02:30:07