Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Transcription from the gene encoding the herpesvirus entry receptor nectin-1 (HveC) in nervous tissue of adult mouse
Autore:
Haarr, L; Shukla, D; Rodahl, E; Dal Canto, MC; Spear, PG;
Indirizzi:
Northwestern Univ, Sch Med, Dept Microbiol Immunol, Chicago, IL 60611 USA Northwestern Univ Chicago IL USA 60611 iol Immunol, Chicago, IL 60611 USA Northwestern Univ, Sch Med, Dept Pathol, Chicago, IL 60611 USA Northwestern Univ Chicago IL USA 60611 Dept Pathol, Chicago, IL 60611 USA Univ Bergen, Haukeland Univ Hosp, Dept Ophthalmol, N-5020 Bergen, Norway Univ Bergen Bergen Norway N-5020 Dept Ophthalmol, N-5020 Bergen, Norway Univ Bergen, Gade Inst, Dept Microbiol & Immunol, Ctr Res Virol, Bergen, Norway Univ Bergen Bergen Norway biol & Immunol, Ctr Res Virol, Bergen, Norway
Titolo Testata:
VIROLOGY
fascicolo: 2, volume: 287, anno: 2001,
pagine: 301 - 309
SICI:
0042-6822(20010901)287:2<301:TFTGET>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
SIMPLEX VIRUS TYPE-1; CELL-ADHESION MOLECULES; POLIOVIRUS RECEPTOR; PSEUDORABIES VIRUS; HEPARAN-SULFATE; MURINE HOMOLOG; ANTEROGRADE TRANSPORT; MEMBRANE-FUSION; GLYCOPROTEIN-H; MEMBER;
Keywords:
HSV; herpes simplex virus; pseudorabies virus; nectin-1; viral entry; mouse; neurons; in situ hybridization;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Spear, PG Northwestern Univ, Sch Med, Dept Microbiol Immunol, Mail Code S213,Room Ward 6-241,320 E Super St, Chicago, IL 60611 USA Northwestern Univ Mail Code S213,Room Ward 6-241,320 E Super St Chicago IL USA 60611
Citazione:
L. Haarr et al., "Transcription from the gene encoding the herpesvirus entry receptor nectin-1 (HveC) in nervous tissue of adult mouse", VIROLOGY, 287(2), 2001, pp. 301-309

Abstract

Both human and murine forms of nectin-1 (HveC, Prr1) can serve as entry receptors for several neurotropic herpesviruses, including herpes simplex viruses 1 and 2 (HSV-1, HSV-2), porcine pseudorabies virus (PRV), and bovine herpesvirus 1. HSV-1, HSV-2, and PRV can cause lethal neurological disease in mice whether inoculation is directly Into the central nervous system or by peripheral routes. Expression of nectin-1 transcripts in cells of the adult mouse nervous system was assessed by in situ hybridization. Specific hybridization signals were detected in neurons in sensory, sympathetic, and parasympathetic ganglia of the peripheral nervous system. In addition, specific signals were observed in neurons of the ventral and dorsal horns of the spinal cord and of the brain stem, cerebellum, cerebral cortex, hippocampus, dentate gyrus, and olfactory bulb. These results show that the nectin-1 gene is widely transcribed in neurons in adult mouse. Nectin-1 is the only known receptor capable of mediating the entry of all three viruses, HSV-1, HSV-2, and PRV. Its pattern of expression in the nervous system suggests a key role in neurological disease caused by these viruses. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 00:51:40