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Titolo:
Molecular genetics of urothelial malignancies: Mismatch repair genes as markers for detection and prognosis?
Autore:
Leach, FS;
Indirizzi:
NCI, Urol Oncol Branch, NIH, Bethesda, MD 20892 USA NCI Bethesda MD USA 20892 Urol Oncol Branch, NIH, Bethesda, MD 20892 USA
Titolo Testata:
UROLOGIC ONCOLOGY
fascicolo: 5, volume: 6, anno: 2001,
pagine: 211 - 219
SICI:
1078-1439(200109/10)6:5<211:MGOUMM>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONPOLYPOSIS COLORECTAL-CANCER; TRANSITIONAL-CELL CARCINOMAS; BLADDER-CANCER; MICROSATELLITE INSTABILITY; COLON-CANCER; URINARY-BLADDER; ALTERED EXPRESSION; SOMATIC MUTATIONS; PROSTATE-CANCER; MUTS HOMOLOG;
Keywords:
mismatch repair; urothelial malignancy; cancer detection; prognosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Leach, FS NCI, Urol Oncol Branch, NIH, 10 Ctr Dr,Bldg 10,Room 2B47, Bethesda, MD 20892 USA NCI 10 Ctr Dr,Bldg 10,Room 2B47 Bethesda MD USA 20892 20892 USA
Citazione:
F.S. Leach, "Molecular genetics of urothelial malignancies: Mismatch repair genes as markers for detection and prognosis?", UROL ONCOL, 6(5), 2001, pp. 211-219

Abstract

Urothelial malignancies were diagnosed in over 50,000 men and women in theUnited States last year. The majority of these tumors are not muscle invasive and can be treated endoscopically with or without adjuvant intravesicaltherapy. Cystoscopy and cytology at regular and frequent intervals are essential since many patients experience tumor recurrence, progression or failto respond to intravesical treatments. Cancer recurrence, progression and intravesical treatment failures can be associated with increased risk of developing metastatic disease if not promptly detected and aggressively treated. Markers that identify patients at increased risk for recurrence, progression and poor response to intravesical therapy would provide useful information in the management of patients with urothelial malignancies. Mismatch repair (MMR) genes are potential markers for detection and prognosis since their expression is linked to tumor predisposition, progression and resistance to chemotherapeutic agents. The molecular biology and biochemistry of MMR will be reviewed and the potential role of human MMR genes for detection, prognosis and treatment of urothelial malignancies will be discussed. (C)2001 Elsevier Science, Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 19:13:08