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Titolo:
Glutamate transporters combine transporter- and channel-like features
Autore:
Slotboom, DJ; Konings, WN; Lolkema, JS;
Indirizzi:
Univ Groningen, Dept Microbiol, Groningen Biomol Sci Biotechnol Inst, NL-9751 NN Haren, Netherlands Univ Groningen Haren Netherlands NL-9751 NN L-9751 NN Haren, Netherlands
Titolo Testata:
TRENDS IN BIOCHEMICAL SCIENCES
fascicolo: 9, volume: 26, anno: 2001,
pagine: 534 - 539
SICI:
0968-0004(200109)26:9<534:GTCTAC>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMINO-ACID TRANSPORTERS; REENTRANT LOOP; RAT-BRAIN; SUBSTRATE-BINDING; CHLORIDE CHANNEL; HIGH-AFFINITY; ION FLUXES; GLT-1; SELECTIVITY; SALAMANDER;
Tipo documento:
Editorial Material
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Slotboom, DJ Univ Groningen, Dept Microbiol, Groningen Biomol Sci Biotechnol Inst, NL-9751 NN Haren, Netherlands Univ Groningen Haren Netherlands NL-9751 NN en, Netherlands
Citazione:
D.J. Slotboom et al., "Glutamate transporters combine transporter- and channel-like features", TRENDS BIOC, 26(9), 2001, pp. 534-539

Abstract

Glutamate transporters in the mammalian central nervous system have a unique position among secondary transport proteins as they exhibit glutamate-gated chloride-channel activity in addition to glutamate-transport activity. In this article, the available data on the structure of the glutamate transporters are compared with high-resolution crystal structures of channel proteins. In addition, binding-site properties of glutamate transporters, and the ligand-binding site of an ionotropic glutamate receptor of which the crystal structure is known, are compared. Possible structural solutions for the combination of channel and transporter activity in one membrane protein are proposed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 14:31:03