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Titolo:
Omega-3 fatty acids enhance tumor necrosis factor-alpha levels in heart transplant recipients
Autore:
Holm, T; Berge, RK; Andreassen, AK; Ueland, T; Kjekshus, J; Simonsen, S; Froland, S; Gullestad, L; Aukrust, P;
Indirizzi:
Univ Oslo, Rikshosp, Dept Cardiol, N-0027 Oslo, Norway Univ Oslo Oslo Norway N-0027 Rikshosp, Dept Cardiol, N-0027 Oslo, Norway Univ Oslo, Rikshosp, Res Inst Internal Med, N-0027 Oslo, Norway Univ OsloOslo Norway N-0027 Res Inst Internal Med, N-0027 Oslo, Norway Univ Oslo, Rikshosp, Dept Endocrinol, Dept Med, N-0027 Oslo, Norway Univ Oslo Oslo Norway N-0027 t Endocrinol, Dept Med, N-0027 Oslo, Norway Univ Oslo, Rikshosp, Sect Clin Immunol & Infect Dis, Dept Med, N-0027 Oslo, Norway Univ Oslo Oslo Norway N-0027 & Infect Dis, Dept Med, N-0027 Oslo, Norway Haukeland Hosp, Div Biochem, N-5021 Bergen, Norway Haukeland Hosp BergenNorway N-5021 , Div Biochem, N-5021 Bergen, Norway
Titolo Testata:
TRANSPLANTATION
fascicolo: 4, volume: 72, anno: 2001,
pagine: 706 - 711
SICI:
0041-1337(20010827)72:4<706:OFAETN>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
COMMON VARIABLE IMMUNODEFICIENCY; DIETARY FISH-OIL; OXIDATIVE STRESS; RHEUMATOID-ARTHRITIS; PROINFLAMMATORY CYTOKINES; ENDOTHELIAL-CELLS; OMEGA-3-FATTY-ACIDS; SUPPLEMENTATION; DISEASE; N-3;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Holm, T Univ Oslo, Rikshosp, Dept Cardiol, Sognsvannsvn 22, N-0027 Oslo, Norway Univ Oslo Sognsvannsvn 22 Oslo Norway N-0027 N-0027 Oslo, Norway
Citazione:
T. Holm et al., "Omega-3 fatty acids enhance tumor necrosis factor-alpha levels in heart transplant recipients", TRANSPLANT, 72(4), 2001, pp. 706-711

Abstract

Background. Proinflammatory cytokines may contribute to clinical complications in heart transplant (HTx) recipients. Previous studies have shown immunodulating effects of omega-3 fatty acids, but the results are somewhat conflicting. In this study, we examined plasma levels of tumor necrosis factoralpha (TNF-alpha), interleukin (IL) 10, and their relations to antioxidantvitamins in 45 HTx recipients before and after treatment with omega-3 fatty acids or placebo. Methods. The patients were long-time survivors of heart transplantation, randomized in a double-blind fashion to receive omega-3 fatty acids (3.4 g/day) or placebo for 1 year. Plasma levels of cytokines were measured by enzyme immunoassays and vitamin A, vitamin E, and beta -carotene by high-performance liquid chromatography. Results. In the omega-3, but not in the placebo group, there was a rise inthe proinflammatory cytokine TNF-alpha (P <0.05), a decrease in the anti-inflammatory cytokine IL-10 (P=0.07), and a rise in TNF/IL-10 ratio (P <0.05) after 12 months, suggesting a proinflammatory net effect. In the omega-3 group, the increase in TNF-alpha was associated with an increase in eicosapentaenoic acid in plasma (r=0.58, P <0.02). During omega-3 fatty-acid treatment, but not during placebo, there was a decrease in vitamin E (P<0.05) and <beta>-carotene (P <0.05) levels, and the decrease in vitamin E was inversely correlated with the increase in TNF-alpha (r=-0.56, P <0.01). The risein TNF-alpha levels during omga-3 fatty acids treatment was most pronounced in those patients with transplant coronary artery disease (P <0.04). Conclusion. Our data suggest that omega-3 fatty acids in HTx recipients may change the balance between proinflammatory and anti-inflammatory cytokines in an inflammatory direction, possibly related to prooxidative effects ofthese fatty acids.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 16:29:00