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Titolo:
TT virus genotype changes frequently in multiply transfused patients with hemophilia but rarely in patients with chronic hepatitis C and in healthy subjects
Autore:
Toyoda, H; Fukuda, Y; Nakano, I; Katano, Y; Yokozaki, S; Hayashi, K; Ito, Y; Suzuki, K; Nakano, H; Saito, H; Takamatsu, J;
Indirizzi:
Nagoya Univ, Sch Med, Dept Transfus Med, Nagoya, Aichi 466, Japan Nagoya Univ Nagoya Aichi Japan 466 Transfus Med, Nagoya, Aichi 466, Japan Nagoya Univ, Sch Med, Dept Internal Med 1, Nagoya, Aichi 466, Japan NagoyaUniv Nagoya Aichi Japan 466 ternal Med 1, Nagoya, Aichi 466, Japan Nagoya Univ, Sch Med, Dept Internal Med 2, Nagoya, Aichi 466, Japan NagoyaUniv Nagoya Aichi Japan 466 ternal Med 2, Nagoya, Aichi 466, Japan Fujita Hlth Univ, Sch Hlth Sci, Dept Publ Hlth, Toyoake, Aichi, Japan Fujita Hlth Univ Toyoake Aichi Japan pt Publ Hlth, Toyoake, Aichi, Japan Fujita Hlth Univ, Sch Med, Dept Internal Med, Toyoake, Aichi 47011, Japan Fujita Hlth Univ Toyoake Aichi Japan 47011 d, Toyoake, Aichi 47011, Japan
Titolo Testata:
TRANSFUSION
fascicolo: 9, volume: 41, anno: 2001,
pagine: 1130 - 1135
SICI:
0041-1132(200109)41:9<1130:TVGCFI>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
A-G HEPATITIS; DNA VIRUS; BLOOD-DONORS; HIGH PREVALENCE; LIVER-DISEASE; POSTTRANSFUSION HEPATITIS; MIXED INFECTIONS; UNKNOWN ETIOLOGY; PCR; HETEROGENEITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Toyoda, H Fac Med Necker Enfants Malad, INSERM U370, 156 Rue Vaugirard, F-75730 Paris 15, France Fac Med Necker Enfants Malad 156 Rue Vaugirard Paris France 15
Citazione:
H. Toyoda et al., "TT virus genotype changes frequently in multiply transfused patients with hemophilia but rarely in patients with chronic hepatitis C and in healthy subjects", TRANSFUSION, 41(9), 2001, pp. 1130-1135

Abstract

BACKGROUND: TT virus (TTV), a novel DNA virus, was originally thought to be transmitted by transfusion. However, nonparenteral transmission is recently suspected to be a major mode of transmission. To investigate the possibility of reinfection with TTV in multiply transfused patients and to evaluate the significance of transfusion transmission of TTV in patients with hemophilia, serial changes in TTV genotype were investigated in three groups. STUDY DESIGN AND METHODS: Serial changes in TTV genotype were investigatedin 16 multiply transfused patients with hemophilia, 16 age-matched patients with chronic hepatitis C, and 16 age-matched healthy subjects. RESULTS: Mixed infection with multiple TTV genotypes was common in all groups. However, changes in TTV genotype were frequent in patients with hemophilia (15/16; 93.8%) but rare in patients with chronic hepatitis C and in healthy subjects (each group: 1/16; 6.3%). CONCLUSION: Changes in TTV genotype were frequently observed in multiply transfused patients with hemophilia but not in patients with chronic hepatitis or in healthy subjects without risk of transfusion transmission. This difference may suggest that exposure to TTV or even reinfection occurs frequently in patients with hemophilia, which could be evidence of transfusion transmission of TTV in this population.

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Documento generato il 27/09/20 alle ore 19:52:03