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Titolo:
Alternative approaches to the identification and characterization of chemical allergens
Autore:
Kimber, I; Pichowski, JS; Betts, CJ; Cumberbatch, M; Basketter, DA; Dearman, RJ;
Indirizzi:
Syngenta Cent Toxicol Lab, Macclesfield SK10 4TJ, Cheshire, England Syngenta Cent Toxicol Lab Macclesfield Cheshire England SK10 4TJ England Unilever Res Labs Colworth, Colworth House, SEAC Toxicol Unit, Sharnbrook MK44 1LQ, Beds, England Unilever Res Labs Colworth Sharnbrook Beds EnglandMK44 1LQ Beds, England
Titolo Testata:
TOXICOLOGY IN VITRO
fascicolo: 4-5, volume: 15, anno: 2001,
pagine: 307 - 312
SICI:
0887-2333(200108/10)15:4-5<307:AATTIA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
LYMPH-NODE ASSAY; EPIDERMAL LANGERHANS CELLS; ANTIGEN-PRESENTING CELLS; NECROSIS-FACTOR-ALPHA; HUMAN DENDRITIC CELLS; IN-VITRO; CONTACT SENSITIZERS; MESSENGER-RNA; HUMAN BLOOD; T-CELLS;
Keywords:
skin sensitization; in vitro methods; predictive tests; dendritic cells; interleukin 1 beta;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Kimber, I Syngenta Cent Toxicol Lab, Macclesfield SK10 4TJ, Cheshire, England Syngenta Cent Toxicol Lab Macclesfield Cheshire England SK10 4TJ
Citazione:
I. Kimber et al., "Alternative approaches to the identification and characterization of chemical allergens", TOX VITRO, 15(4-5), 2001, pp. 307-312

Abstract

Chemical allergy can take a variety of forms, those of greatest importancein an occupational setting being skin sensitization resulting in allergic contact dermatitis and sensitization of the respiratory tract associated with asthma and other symptoms. In both cases there is a need for predictive test methods that allow the accurate identification of sensitizing chemicals. Well characterized methods are available for skin sensitization testing,and although to date no tests for respiratory sensitization have been formally validated, progress has been made in defining suitable animal models. In recent years there have been significant advances in our understanding of the cellular and molecular mechanisms through which allergic sensitization to chemicals is induced and regulated. Such progress provides us now withnew opportunities to consider alternative approaches to sensitization testing, including the design of in vitro test methods. The greatest investmenthas been in exploring novel methods for the identification of contact sensitizers and it is upon this aspect of chemical allergy that this article isfocused. Described here are some of the general requirements of in vitro test methods for skin sensitization, and progress that has been made in developing suitable approaches with particular emphasis on the utility of dendritic cell culture systems. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 05:09:21