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Titolo:
Toxic effects of tamoxifen on the growth and respiratory activity of Bacillus stearothermophilus
Autore:
Luxo, C; Jurado, AS; Custodio, JBA; Madeira, VMC;
Indirizzi:
Univ Coimbra, Fac Farm, Microbiol Lab, P-3049517 Coimbra, Portugal Univ Coimbra Coimbra Portugal P-3049517 Lab, P-3049517 Coimbra, Portugal Univ Coimbra, Ctr Neurociencias, P-3049517 Coimbra, Portugal Univ CoimbraCoimbra Portugal P-3049517 ias, P-3049517 Coimbra, Portugal Univ Coimbra, Fac Farm, Lab Bioquim, P-3049517 Coimbra, Portugal Univ Coimbra Coimbra Portugal P-3049517 uim, P-3049517 Coimbra, Portugal
Titolo Testata:
TOXICOLOGY IN VITRO
fascicolo: 4-5, volume: 15, anno: 2001,
pagine: 303 - 305
SICI:
0887-2333(200108/10)15:4-5<303:TEOTOT>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
MODEL; ANTIESTROGENS;
Keywords:
tamoxifen; Bacillus stearothermophilus; bacterial growth; respiratory activity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Luxo, C Univ Coimbra, Fac Farm, Microbiol Lab, P-3049517 Coimbra, PortugalUniv Coimbra Coimbra Portugal P-3049517 049517 Coimbra, Portugal
Citazione:
C. Luxo et al., "Toxic effects of tamoxifen on the growth and respiratory activity of Bacillus stearothermophilus", TOX VITRO, 15(4-5), 2001, pp. 303-305

Abstract

The anticancer drug tamoxifen (TAM) is used as first line therapy in breast cancer. Although tamoxifen is usually considered an estrogen antagonist, several studies suggest alternative mechanisms of action. Bacillus stearothermophilus has been used as a model to clarify the antiproliferative actionof tamoxifen putatively related with drug-membrane interaction. According to previous data, TAM induces perturbation of membrane structure along withimpairment of bacterial growth. The aim of this work was to correlate the effects of TAM on growth of intact B. stearothermophilus with the respiratory activity of isolated protoplasts of this bacteria. TAM inhibits bacterial growth and oxygen consumption of protoplasts as a function of concentration. Effects on oxygen consumption depend on the substrate used: NADH, allowing to study the full respiratory chain and ascorbate-TMPD to probe the final oxidase segment. The interaction of TAM with the respiratory components occurs at a level preceding the cytochrome oxidase segment. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 16:35:44