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Titolo:
Thrombophilic risk factors in patients with central retinal vein occlusion
Autore:
Marcucci, R; Bertini, L; Giusti, B; Brunelli, T; Fedi, S; Cellai, AP; Poli, D; Pepe, G; Abbate, R; Prisco, D;
Indirizzi:
Univ Florence, Azienda Osped Careggi, Ctr Trombosi, Dip Area Cri Med Chirurg, I-50134 Florence, Italy Univ Florence Florence Italy I-50134 ed Chirurg, I-50134 Florence, Italy
Titolo Testata:
THROMBOSIS AND HAEMOSTASIS
fascicolo: 3, volume: 86, anno: 2001,
pagine: 772 - 776
SICI:
0340-6245(200109)86:3<772:TRFIPW>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVATED PROTEIN-C; HIGH LIPOPROTEIN(A) LEVELS; FACTOR-V-LEIDEN; PLASMA HOMOCYSTEINE; YOUNG-ADULTS; PROTHROMBIN GENE; ARTERY-OCCLUSION; HEART-DISEASE; RESISTANCE; HYPERHOMOCYSTEINEMIA;
Keywords:
central retinal vein occlusion; homocysteine; genetic polymorphisms; fibrinolysis; risk factors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Prisco, D Univ Florence, Azienda Osped Careggi, Ctr Trombosi, Dip Area CriMed Chirurg, V Morgagni 85, I-50134 Florence, Italy Univ Florence V Morgagni 85 Florence Italy I-50134 rence, Italy
Citazione:
R. Marcucci et al., "Thrombophilic risk factors in patients with central retinal vein occlusion", THROMB HAEM, 86(3), 2001, pp. 772-776

Abstract

Few and contra-sting, data are available on the prevalence of hemostatic risk factors in patients with central retinal vein occlusion (CRVO). Aim of this study was to investigate the metabolic and a inherited risk factors for venous thrombosis in 100 CRVO patients (age: 59 yrs; range 18-77) and in 100 controls (age: 56 yrs; range 18-84). In patients homocysteine (Hey) levels were significantly higher than in controls and were affected by the C677T methylenetetrahydrofolate reductase (MTHFR) polymorphism (p < 0.001). The prevalences of activated protein C resistance (APCR), factor V Leiden positivity, elevated PAI-1 and Lp(a) levels were significantly higher in patients with respect to controls. At multivariate analysis, only hyperhomo-cysteinemia (OR 11, 95% Cl 36-36.2; p < 0.0001) and elevated PAI-1 levels (OR 8.9. 95% Cl 3.5-41.3; p < 0.01), in addition to hypertension (OR 40.5. 95% Cl 8.6-188.8; p < 0.00001) and hypercholesterolemia (OR 3.1, 95% Cl 1.6-20.5; p < 0.05), were independent risk factors for CRVO. These data demonstratea potential role of hemostatic risk factors in the pathophysiology of CRVO.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 21:07:51