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Titolo:
Protective effect of endothelin type A receptor antagonist on brain edema and injury after transient middle cerebral artery occlusion in rats
Autore:
Matsuo, Y; Mihara, S; Ninomiya, M; Fujimoto, M;
Indirizzi:
Shionogi & Co Ltd, Discovery Res Labs, Toyonaka, Osaka, Japan Shionogi & Co Ltd Toyonaka Osaka Japan Res Labs, Toyonaka, Osaka, Japan
Titolo Testata:
STROKE
fascicolo: 9, volume: 32, anno: 2001,
pagine: 2143 - 2148
SICI:
0039-2499(200109)32:9<2143:PEOETA>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE ISCHEMIC STROKE; POSTISCHEMIC HYPOPERFUSION; BARRIER PERMEABILITY; NEUTROPHIL DEPLETION; PLASMA ENDOTHELIN-1; GLOBAL-ISCHEMIA; BLOOD-FLOW; CELLS; PATHOGENESIS; REPERFUSION;
Keywords:
blood-brain barrier; brain edema; brain injuries; cerebral ischemia, focal; endothelins; rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Matsuo, Y Shionogi & Co Ltd, Discovery Res Labs, 3-1-1 Futaba Cho, Toyonaka, Osaka, Japan Shionogi & Co Ltd 3-1-1 Futaba Cho Toyonaka Osaka Japan , Japan
Citazione:
Y. Matsuo et al., "Protective effect of endothelin type A receptor antagonist on brain edema and injury after transient middle cerebral artery occlusion in rats", STROKE, 32(9), 2001, pp. 2143-2148

Abstract

Background and Purpose-Recent evidence strongly suggests that endothelins (ETs) play an important role in the regulation of blood-brain barrier (BBB)functions. The aim of the present study was to evaluate the role of ETs onedema formation and BBB permeability change after cerebral ischemia/reperfusion. Methods-We examined the brain tissue ET-1 content and evaluated the time and dose response of the therapeutic effects of the specific ET type A receptor (ETA) antagonist, S-0139, on brain edema formation, development of infarction, and disruption of BBB after I hour of middle cerebral artery occlusion (MCAO) in rats. Results-After 1-hour MCAO and reperfusion, the brain ET-1 content did not change during the first 3 hours, increased at 6 hours, and rose almost continuously over 48 hours in the ischemic region as well as in the ischemic rim. Rats infused with S-0139 (0.03 to 1.0 mg/kg per hour) during reperfusionshowed dose-dependent and significant attenuation of the increase in brainwater content 24 hours after reperfusion. When the infusion of S-0139 was begun after 10 minutes and 1 hour of reperfusion, the brain edema formationand infarct size were significantly attenuated. Furthermore, posttreatmentwith S-0139 significantly attenuated the increased Evans blue dye-quantified albumin extravasation and improved the mortality of animals after cerebral ischemia/reperfusion. Conclusions-Our data demonstrate that infusion with S-0139, an ETA antagonist, results in significant reduction of brain injury and plasma extravasation after transient MCAO. Thus, ETs may contribute to cerebral ischemia/reperfusion injury at least partly by increasing the BBB permeability via ETAS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/08/20 alle ore 19:40:51