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Titolo:
Axonal conduction properties of antidromically identified neurons in rat barrel cortex
Autore:
Kelly, MK; Carvell, GE; Hartings, JA; Simons, DJ;
Indirizzi:
Univ Pittsburgh, Dept Phys Therapy, Sch Hlth & Rehabil Sci, Pittsburgh, PA15260 USA Univ Pittsburgh Pittsburgh PA USA 15260 abil Sci, Pittsburgh, PA15260 USA Univ Pittsburgh, Sch Med, Dept Neurobiol, Pittsburgh, PA 15260 USA Univ Pittsburgh Pittsburgh PA USA 15260 urobiol, Pittsburgh, PA 15260 USA
Titolo Testata:
SOMATOSENSORY AND MOTOR RESEARCH
fascicolo: 3, volume: 18, anno: 2001,
pagine: 202 - 210
SICI:
0899-0220(2001)18:3<202:ACPOAI>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRIMARY SOMATOSENSORY CORTEX; RECEPTIVE-FIELDS; SUSPECTED INTERNEURONS; EFFERENT NEURONS; AWAKE RABBIT; MOTOR CORTEX; CORTICOFUGAL AXONS; VIBRISSA CORTEX; PROJECTIONS; CELLS;
Keywords:
antidromic stimulation; barrel cortex; cortical efferents; local circuits; cerebral peduncles; thalamus; motor cortex;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Kelly, MK Univ Pittsburgh, Dept Phys Therapy, Sch Hlth & Rehabil Sci, 6035Forbes Tower, Pittsburgh, PA 15260 USA Univ Pittsburgh 6035 Forbes Tower Pittsburgh PA USA 15260 60 USA
Citazione:
M.K. Kelly et al., "Axonal conduction properties of antidromically identified neurons in rat barrel cortex", SOMAT MOT R, 18(3), 2001, pp. 202-210

Abstract

Physiological studies of the rodent somatosensory cortex have consistentlydescribed considerable heterogeneity in receptive field properties of neurons outside of layer IV, particularly those in layers V and VI. One such approach for distinguishing among different local circuits in these layers may be to identify the projection target of neurons whose axon collaterals contribute to the local network. In vivo, this can be accomplished using antidromic stimulation methods. Using this approach, the axonal conduction properties of cortical efferent neurons are described. Four projection sites were activated using electrical stimulation: (1) vibrissal motor cortex, (2) ventrobasal thalamus (VB), (3) posteromedial thalamic nucleus (POm), and (4) cerebral peduncle. Extracellular recordings were obtained from a total of169 units in 21 animals. Results demonstrate a close correspondence between the laminar location of the antidromically identified neurons and their anatomically known layer of origin. Axonal properties were most distinct forcorticofugal axons projecting through the crus cerebri. Corticothalamic axons projecting to either VB or POm were more similar to each other in termsof laminar location and conduction properties, but could be distinguished using focal electrical stimulation. It is concluded that, once stimulation parameters are adjusted for the small volume of the rat brain, the use of antidromic techniques may be an effective strategy to differentiate among projection neurons comprising different local circuits in supra- and infragranular circuits.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 15:07:44