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Titolo:
Reversible temperature-sensitive alterations in lung fluid balance
Autore:
John, TA; Vogel, SM; Sekosan, M; Malik, AB;
Indirizzi:
Univ Illinois, Coll Med, Dept Pharmacol, Chicago, IL 60612 USA Univ Illinois Chicago IL USA 60612 Dept Pharmacol, Chicago, IL 60612 USA Univ Illinois, Coll Med, Dept Pathol, Chicago, IL 60612 USA Univ IllinoisChicago IL USA 60612 ed, Dept Pathol, Chicago, IL 60612 USA
Titolo Testata:
SHOCK
fascicolo: 4, volume: 16, anno: 2001,
pagine: 294 - 297
SICI:
1073-2322(200110)16:4<294:RTAILF>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
ISCHEMIA-REPERFUSION INJURY; RAT LUNG; PRESERVATION; HYPOTHERMIA; MODEL; CLEARANCE; LIQUID;
Keywords:
edema; hypothermia; pulmonary vasoconstriction; ouabain; (Na+,K+)-ATPase; vascular endothelium;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Malik, AB Univ Illinois, Coll Med, Dept Pharmacol, 835 S Wolcott Ave M-C 868, Chicago, IL 60612 USA Univ Illinois 835 S Wolcott Ave M-C 868 Chicago IL USA 60612 USA
Citazione:
T.A. John et al., "Reversible temperature-sensitive alterations in lung fluid balance", SHOCK, 16(4), 2001, pp. 294-297

Abstract

Hypothermia is intentionally imposed during the harvesting of lungs for transplantation. The aim of this study was to investigate the fluid balance alterations in rat lung preparations exposed to hypothermic perfusion. Lowering perfusate temperature from 37 degreesC to values between 27 and 7 degreesC caused an immediate, marked pulmonary hypertension and vasoconstrictionaccompanied by rapid development of pulmonary edema (+1.15 g, or similar to 90%, gain in lung weight within 5 min). However, on rewarming, vasoconstriction was immediately reversed. Edema was resolved, but along a two-component time course: an immediate reduction of lung weight on rewarming (t(1/2)of 0.5 min) that mirrored the recovery of pulmonary artery pressure and vasoconstriction, and also a slower pressure-independent component of recovery (t(1/2) of 3.5 min). Ouabain (300 muM) markedly inhibited the lung's ability to recover from edema, indicating that fluid clearance from lung tissuewas the result of activation of ouabain-sensitive (Na+,K+)-ATPase pump. Results could not be explained by vascular or airspace injury as lung sections from hypothermic lungs appeared normal. The findings indicate that hypothermia induces pulmonary edema formation, which can be rapidly cleared upon rewarming by activation of ouabain -sensitive (Na+,K+)-ATPase pump. Thus, impaired fluid clearance from lung extravascular spaces may be a critical factor limiting gas exchange in transplanted lungs exposed to hypothermia.

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Documento generato il 03/04/20 alle ore 11:01:41