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Titolo:
No evidence for dependence of early cortical auditory processing on dopamine D-2-receptor modulation: a whole-head magnetoencephalographic study
Autore:
Kahkonen, S; Ahveninen, J; Pekkonen, E; Kaakkola, S; Huttunen, J; Peltonen, T; Ilmoniemi, RJ; Jaaskelainen, IP;
Indirizzi:
Univ Helsinki, Cent Hosp, Med Engn Ctr, BioMag Lab, FIN-00029 Helsinki, Finland Univ Helsinki Helsinki Finland FIN-00029 ab, FIN-00029 Helsinki, Finland Univ Helsinki, Dept Psychol, Cognit Brain Res Unit, SF-00100 Helsinki, Finland Univ Helsinki Helsinki Finland SF-00100 Unit, SF-00100 Helsinki, Finland Univ Helsinki, Cent Hosp, Dept Clin Neurosci, Helsinki, Finland Univ Helsinki Helsinki Finland p, Dept Clin Neurosci, Helsinki, Finland Univ Helsinki, Cent Hosp, Dept Clin Neurophysiol, Helsinki, Finland Univ Helsinki Helsinki Finland ept Clin Neurophysiol, Helsinki, Finland
Titolo Testata:
PSYCHIATRY RESEARCH-NEUROIMAGING
fascicolo: 2, volume: 107, anno: 2001,
pagine: 117 - 123
SICI:
0925-4927(20010825)107:2<117:NEFDOE>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
EVOKED-POTENTIALS; MIDDLE-LATENCY; HUMAN-BRAIN; HALOPERIDOL; RECEPTORS; CORTEX; NEUROLEPTICS;
Keywords:
auditory; D-2 receptors; dopamine; event-related magnetic field; haloperidol; magnetoencephalography (MEG); middle-latency auditory evoked magnetic field (MAEF);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Kahkonen, S Univ Helsinki, Cent Hosp, Med Engn Ctr, BioMag Lab, POB 340, FIN-00029 Helsinki, Finland Univ Helsinki POB 340 Helsinki Finland FIN-00029 nki, Finland
Citazione:
S. Kahkonen et al., "No evidence for dependence of early cortical auditory processing on dopamine D-2-receptor modulation: a whole-head magnetoencephalographic study", PSYCH RES-N, 107(2), 2001, pp. 117-123

Abstract

Magnetoencephalography (MEG) was used to determine the effect of neuroleptic challenge on brain responses in healthy subjects. In a double-blind, randomized, placebo-controlled, cross-over design study, the dopamine D-2 receptor antagonist haloperidol (2 mg) was given orally to 12 healthy volunteers. The middle-latency auditory evoked magnetic fields (MAEF) were recorded 3 h after administration of haloperidol or placebo with a whole-head 122-channel MEG. Haloperidol did not significantly affect MAEF responses. The dipole moments and source locations of the responses were not significantly influenced by haloperidol. These results suggest that dopamine D-2 receptors are not involved in the early phases of auditory cortical processing. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

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Documento generato il 22/01/20 alle ore 18:42:49