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Titolo:
alpha(2)-Adrenoceptor antagonists: effects on ejaculation, penile erectionand pelvic thrusting behavior in dogs
Autore:
Yonezawa, A; Ando, R; Watanabe, C; Furuta, S; Kutsuwa, M; Sakurada, S; Kimura, Y;
Indirizzi:
Tohoku Pharmaceut Univ, Dept Physiol & Anat, Aoba Ku, Sendai, Miyagi 9818558, Japan Tohoku Pharmaceut Univ Sendai Miyagi Japan 9818558 Miyagi 9818558, Japan Tohoku Pharmaceut Univ, Ctr Lab Anim Sci, Aoba Ku, Sendai, Miyagi 9818558,Japan Tohoku Pharmaceut Univ Sendai Miyagi Japan 9818558 , Miyagi 9818558,Japan Towada Urol Hosp, Towada, Aomori 0340003, Japan Towada Urol Hosp Towada Aomori Japan 0340003 owada, Aomori 0340003, Japan
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 1, volume: 70, anno: 2001,
pagine: 141 - 147
SICI:
0091-3057(200109)70:1<141:AAEOEP>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
MALE SEXUAL-BEHAVIOR; MALE-RATS; ALPHA-2-ADRENOCEPTOR ANTAGONIST; FREQUENT EJACULATION; MATING-BEHAVIOR; YOHIMBINE; ENHANCEMENT; MODULATION; MOTIVATION; REFLEXES;
Keywords:
alpha(2)-Adrenoceptor antagonist; ejaculation; penile erection; pelvic thrusting behavior; dog;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Yonezawa, A Tohoku Pharmaceut Univ, Dept Physiol & Anat, Aoba Ku, 4-4-1 Komatsushima, Sendai, Miyagi 9818558, Japan Tohoku Pharmaceut Univ 4-4-1 Komatsushima Sendai Miyagi Japan 9818558
Citazione:
A. Yonezawa et al., "alpha(2)-Adrenoceptor antagonists: effects on ejaculation, penile erectionand pelvic thrusting behavior in dogs", PHARM BIO B, 70(1), 2001, pp. 141-147

Abstract

We previously reported that systemic administration of yohimbine, an alpha(2)-adrenoceptor antagonist, experts a biphasic effect (stimulating and suppressing) on ejaculation in dogs, when this function is analyzed using theamount of ejaculated semen in repose to genital stimulation. To clarify the effect of alpha (2)-adrenoceptor blockade on male sexual function, we investigated the effects of four selective alpha (2)-adrenoceptor antagonists,rauwolscine, idazoxan, RX821002 and mydaglizole, on sexual responses (ejaculation, penile erection and pelvic thrusting behavior) elicited by manual penile stimulation in dogs. Rauwolscine (intraperitoneal, 30 min before thetesting) caused a biphasic effect on ejaculation; the amount of ejaculatedsemen produced by the stimulation was significantly increased by the lowerdoses (0.1 and 0.3 mg.kg), whereas it was decreased by the higher doses (1.0 and 2.0 mg/kg). The higher doses of rawolscine also markedly inhibited both penile erection and pelvic thrusting behavior. Idazoxan and RX821001, at doses of 0.1 and 0.3 mg/kg, caused a significant increase in the amount of ejaculted semen without affecting other sexual functions. RX821002 (2.0 mg/kg), but not idazoxan (2.0 mg/kg), moderately inhibited both penile erection and pelvic thrusting behavior. Mydaglizole, a peripherally acting alpha(2)-adrenoceptor antagonist (0.1 mg/kg), except for mydaglizole, completely prevented the decrease in ejaculatory capacity produced by antedecent ejaculation. These results indicate that, though the range of the effective dose is narrow, the alpha (2)-adrenoceptor antagonists that can block the central alpha (2)-adrenoceptors have the stimulatory effects on ejaculatory function. The difference of the sexual effects may be based on the action except for the alpha (2)-adrenoceptor blockade. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/02/20 alle ore 04:56:33