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Titolo:
Aspects on the pathophysiology of migraine and cluster headache
Autore:
Edvinsson, L;
Indirizzi:
Univ Lund Hosp, Dept Internal Med, S-22185 Lund, Sweden Univ Lund Hosp Lund Sweden S-22185 pt Internal Med, S-22185 Lund, Sweden
Titolo Testata:
PHARMACOLOGY & TOXICOLOGY
fascicolo: 2, volume: 89, anno: 2001,
pagine: 65 - 73
SICI:
0901-9928(200108)89:2<65:AOTPOM>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-RELATED PEPTIDE; EXTRACEREBRAL CIRCULATION; NEUROPEPTIDE CHANGES; TRIGEMINOVASCULAR ACTIVATION; CEREBRAL-CIRCULATION; FUNCTIONAL-ROLE; BLOOD-VESSELS; NERVE-FIBERS; SUBSTANCE-P; BRAIN-STEM;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Edvinsson, L Univ Lund Hosp, Dept Internal Med, S-22185 Lund, Sweden Univ Lund Hosp Lund Sweden S-22185 ed, S-22185 Lund, Sweden
Citazione:
L. Edvinsson, "Aspects on the pathophysiology of migraine and cluster headache", PHARM TOX, 89(2), 2001, pp. 65-73

Abstract

The specific cause of migraine headache remains unknown. Current theories suggest that the initiation of a migraine attack involves a primary CNS dysfunction with subsequent activation of the trigeminovascular system. Studies in patients have revealed a clear association between headache and the release of the neuropeptide calcitonin gene-related peptide, probably from C fibres. In cluster headache and in a case of chronic paroxysmal headache there was in addition release of the parasympathetic neuropeptide vasoactive intestinal peptide, which was associated with headache, nasal congestion and rhinorrhea. Triptan administration, activating the 5-HT1B/1D receptors. caused the headache to subside and the neuropeptide release to normalise. These data suggest the involvement of sensory and parasympathetic mechanisms in the pathophysiology of primary headaches.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 02:53:12