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Titolo:
Population-based active surveillance for neonatal group B streptococcal infections in Alberta, Canada: implications for vaccine formulation
Autore:
Davies, HD; Raj, S; Adair, C; Robinson, J; McGeer, A;
Indirizzi:
Univ Calgary, Alberta Childrens Prov Gen Hosp, Child Hlth Res Unit, Div Infect Dis, Calgary, AB T2T 5C7, Canada Univ Calgary Calgary AB Canada T2T 5C7 t Dis, Calgary, AB T2T 5C7, Canada Univ Calgary, Alberta Childrens Prov Gen Hosp, Dept Microbiol & Infect Dis, Calgary, AB T2T 5C7, Canada Univ Calgary Calgary AB Canada T2T 5C7 t Dis, Calgary, AB T2T 5C7, Canada Univ Calgary, Alberta Childrens Prov Gen Hosp, Dept Pediat, Calgary, AB T2T 5C7, Canada Univ Calgary Calgary AB Canada T2T 5C7 ediat, Calgary, AB T2T 5C7, Canada Univ Calgary, Alberta Childrens Prov Gen Hosp, Dept Community Hlth, Calgary, AB T2T 5C7, Canada Univ Calgary Calgary AB Canada T2T 5C7 Hlth, Calgary, AB T2T 5C7, Canada Univ Alberta, Stollery Childrens Hlth Ctr, Edmonton, AB, Canada Univ Alberta Edmonton AB Canada Childrens Hlth Ctr, Edmonton, AB, Canada Univ Toronto, Mt Sinai Hosp, Shared Dept Microbiol, Toronto, ON M5G 1X5, Canada Univ Toronto Toronto ON Canada M5G 1X5 obiol, Toronto, ON M5G 1X5, Canada Univ Toronto, Princess Margaret Hosp, Shared Dept Microbiol, Toronto, ON M5G 1X5, Canada Univ Toronto Toronto ON Canada M5G 1X5 obiol, Toronto, ON M5G 1X5, Canada
Titolo Testata:
PEDIATRIC INFECTIOUS DISEASE JOURNAL
fascicolo: 9, volume: 20, anno: 2001,
pagine: 879 - 884
SICI:
0891-3668(200109)20:9<879:PASFNG>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
TOXOID CONJUGATE VACCINE; ALPHA-C-PROTEIN; CAPSULAR POLYSACCHARIDE; SEROTYPE-V; DISEASE; IMMUNOGENICITY; ADULTS; WOMEN; IMMUNIZATION; EPIDEMIOLOGY;
Keywords:
group B Streptococcus; serotype; immunity; Alberta; Canada; neonate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Davies, HD Univ Calgary, Alberta Childrens Prov Gen Hosp, Child Hlth Res Unit, Div Infect Dis, 1820 Richmond Rd SW, Calgary, AB T2T 5C7, Canada Univ Calgary 1820 Richmond Rd SW Calgary AB Canada T2T 5C7 nada
Citazione:
H.D. Davies et al., "Population-based active surveillance for neonatal group B streptococcal infections in Alberta, Canada: implications for vaccine formulation", PEDIAT INF, 20(9), 2001, pp. 879-884

Abstract

Background. Knowledge of circulating serotypes of group B Streptococcus (GBS) is important for formulation of vaccines. There are no Canadian data onthe serotype distribution of neonatal GBS isolates. Methods. Using a retrospective laboratory and health record survey between1993 and 1994 (before introduction of Canadian prevention guidelines) and prospective active laboratory-based surveillance from 1995 to 1999 of all laboratories in Alberta, we identified 168 cases of invasive neonatal GBS infections including stillbirths among 262 398 total births; 118 of 123 (96%)isolates from 1995 to 1999 were serotyped, and the corresponding neonatal health records were reviewed. Results. The average annual incidence was 0.64 of 1000 total births/year. Of these 95 (57%) had early onset disease (EOD), 15 (9%) were still births and 58 (34%) had late onset disease (LOD). Eighty-one percent of EOD cases were caused by serotypes a, Ia/c, Ia/c/R, III, IILIR and V, V/R, whereas 81% of LOD cases were caused by serotypes III and III/R. GBS serotypes containing the C protein along with serotypes III and V as a group constituted 91% (107 of 118) of all GBS cases in our population. The most common clinicalpresentation was bacteremia without focus (74%) followed by meningitis (14%) and pneumonia (12%). During 1995 to 1999, in addition to 13 stillbirths,there were 6 of 64 (9%) neonatal deaths among EOD cases and 1 of 46 (2%) neonatal death among LOD cases. Conclusions. In this population-based study stillbirths account for a proportion of cases that are not routinely counted and represent a group for which intrapartum antibiotics would likely not be effective, but potentially preventable by vaccination. Inclusion of serotypes Ia, III and V in a conjugate vaccine or serotypes III and V conjugated with the C protein in a GBS vaccine could theoretically provide protection against the majority of GBS invasive disease in Alberta neonates.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 12:44:30