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Titolo:
High prevalence of erythromycin resistance of Streptococcus pyogenes in Greek children
Autore:
Syrogiannopoulos, GA; Grivea, IN; Fitoussi, F; Doit, C; Katopodis, GD; Bingen, E; Beratis, NG;
Indirizzi:
Univ Patras, Sch Med, Dept Pediat, Div Infect Dis, Patras 26500, Greece Univ Patras Patras Greece 26500 at, Div Infect Dis, Patras 26500, Greece Hop Robert Debre, Microbiol Serv, F-75019 Paris, France Hop Robert Debre Paris France F-75019 robiol Serv, F-75019 Paris, France
Titolo Testata:
PEDIATRIC INFECTIOUS DISEASE JOURNAL
fascicolo: 9, volume: 20, anno: 2001,
pagine: 863 - 868
SICI:
0891-3668(200109)20:9<863:HPOERO>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-HEMOLYTIC STREPTOCOCCI; GROUP-A STREPTOCOCCI; MACROLIDE RESISTANCE; ANTIMICROBIAL RESISTANCE; PHENOTYPES; SPAIN; SUSCEPTIBILITY; CLINDAMYCIN; ANTIBIOTICS; MECHANISMS;
Keywords:
erythromycin resistance; Streptococcus pyogenes; Greece;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Syrogiannopoulos, GA Univ Patras, Sch Med, Dept Pediat, Div Infect Dis, Patras 26500, Greece Univ Patras Patras Greece 26500 atras 26500, Greece
Citazione:
G.A. Syrogiannopoulos et al., "High prevalence of erythromycin resistance of Streptococcus pyogenes in Greek children", PEDIAT INF, 20(9), 2001, pp. 863-868

Abstract

Background. Macrolide resistance among Streptococcus pyogenes strains is increasing in many European countries. Greece was not considered a country with high prevalence of macrolide-resistant S. pyogenes strains, and until now the genetic mechanism of resistance was unknown. Methods. During the 25-month period from December, 1998, to December, 2000, pharyngeal cultures for S. pyogenes were performed on 743 Greek children with the clinical diagnosis of pharyngitis. The children were 1 to 16 yearsold (median age, 7 years) and were living in Central and Southern Greece. S. pyogenes isolates were tested for their susceptibility to erythromycin, clarithromycin, azithromycin, clindamycin, penicillin G, amoxicillin/clavulanate and cefprozil. The erythromycin-resistant isolates were further studied for their genetic mechanism of resistance by means of PCR. Results. Of a total of 275 S. pyogenes isolates recovered, 105 (38%) were erythromycin-resistant (MIC less than or equal to 1 mug/ml), with 54, 45 and 1% of them carrying mef(A), erm(A) [subclass erm(TR)] and erm(B) gene, respectively. The prevalence of erythromycin-resistant strains was 29 and 42%during the time periods December, 1998, to December, 1999, and January, 2000, to December, 2000, respectively. All erythromycin-resistant isolates were also resistant to clarithromycin and azithromycin. The isolates carryingthe erm(A) gene were inducibly resistant to clindamycin. The 275 S. pyogenes isolates had ceprozil MICs less than or equal to 0.032 mug/ml.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 18:49:27