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Titolo:
Genetic polymorphism of CYP1A1, GSTM1 and GSTT1 genes in Indian oral cancer
Autore:
Sreelekha, TT; Ramadas, K; Pandey, M; Thomas, G; Nalinakumari, KR; Pillai, MR;
Indirizzi:
Reg Canc Ctr, Dept Lab Med, Thiruvananthapuram 695011, Kerala, India Reg Canc Ctr Thiruvananthapuram Kerala India 695011 695011, Kerala, India Reg Canc Ctr, Dept Radiat Oncol, Thiruvananthapuram 695011, Kerala, India Reg Canc Ctr Thiruvananthapuram Kerala India 695011 695011, Kerala, India Reg Canc Ctr, Dept Surg Oncol, Thiruvananthapuram 695011, Kerala, India Reg Canc Ctr Thiruvananthapuram Kerala India 695011 695011, Kerala, India Reg Canc Ctr, Dept Community Oncol, Thiruvananthapuram 695011, Kerala, India Reg Canc Ctr Thiruvananthapuram Kerala India 695011 695011, Kerala, India Reg Canc Ctr, Dept Dent Care, Thiruvananthapuram 695011, Kerala, India RegCanc Ctr Thiruvananthapuram Kerala India 695011 695011, Kerala, India
Titolo Testata:
ORAL ONCOLOGY
fascicolo: 7, volume: 37, anno: 2001,
pagine: 593 - 598
SICI:
1368-8375(200110)37:7<593:GPOCGA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
SQUAMOUS-CELL CARCINOMA; S-TRANSFERASE GENES; LUNG-CANCER; GLUTATHIONE TRANSFERASE; NULL GENOTYPE; CYTOCHROME-P450IA1 GENE; JAPANESE POPULATION; RISK; SUSCEPTIBILITY; SMOKING;
Keywords:
CYP1A1; GSTM1; GSTT1; polymorphism; susceptibility; oral cancer;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Pillai, MR Reg Canc Ctr, Dept Lab Med, Thiruvananthapuram 695011, Kerala, India Reg Canc Ctr Thiruvananthapuram Kerala India 695011 ala, India
Citazione:
T.T. Sreelekha et al., "Genetic polymorphism of CYP1A1, GSTM1 and GSTT1 genes in Indian oral cancer", ORAL ONCOL, 37(7), 2001, pp. 593-598

Abstract

Oral cancer ranks first among all cancers in males and is the third most common among females in India. Tobacco-derived carcinogens are involved in the development of oral cancer. Environment-gene interaction in oral carcinogenesis is well demonstrated by phase I and II enzymes that are involved inthe metabolism of carcinogens. This study looked at the significance of genetic polymorphisms in CYP1A1, GSTM1 and GSTT1 genes in patients with oral cancer. The study included 98 oral cancer patients and 60 age and sex matched healthy controls. Genotypes of CYP1A1, GSTM1 and GSTT1 were determined by PCR-RFLP. GSTM1 null deletion was observed in 49% of oral cancer cases and 33% of control subjects. For GSTT1, 18% of carcinomas and 8% of controls had the null genotype. In the case of CYP1A1 m2 allele, 51% of oral cancersand 17% of normal controls, respectively, had one or both alleles with theisoleucine --> valine substitution. Digestion of the PCR products with enzyme Nco1 revealed polymorphism for CYP1A1 m2 with bands at 263 bp. There was no association between genotypes with tumor size, stage, grade, and age. Since null genotype individuals may possibly be poor detoxifiers with reduced ability to neutralise the reactive carcinogenic intermediates, they may be a high risk category. The frequency distribution of CYP1A1 m2 (Ile/val) genotypes among oral cancer patients was significantly different that from normal controls. The risk of CYP1A1 can be supported by the functional difference between presence of valine and isoleucine; valine type has higher catalytic and mutagenic activity towards benzo[a] pyrene than the isoleucine type, In conclusion, our results suggest that polymorphism in CYP1A1 m2 gene and/or GSTM1 and GSTT1 null genotype may confer an increased risk for oral cancer. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 09:57:32