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Titolo:
Expression of p53 in oral squamous cell carcinoma and its association withrisk habits in southern Thailand
Autore:
Kerdpon, D; Sriplung, H; Kietthubthew, S;
Indirizzi:
Prince Songkla Univ, Fac Dent, Dept Stomatol, Hat Yai 90112, Songkhla, Thailand Prince Songkla Univ Hat Yai Songkhla Thailand 90112 2, Songkhla, Thailand Prince Songkla Univ, Fac Med, Dept Pathol, Hat Yai 90112, Songkhla, Thailand Prince Songkla Univ Hat Yai Songkhla Thailand 90112 2, Songkhla, Thailand
Titolo Testata:
ORAL ONCOLOGY
fascicolo: 7, volume: 37, anno: 2001,
pagine: 553 - 557
SICI:
1368-8375(200110)37:7<553:EOPIOS>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN; OVEREXPRESSION; MUTATIONS; SMOKING; TAIWAN; HEAD; NECK; INCREASES; LESIONS; CANCERS;
Keywords:
p53; immunohistochemistry; oral squamous cell carcinoma; betel quid; tobacco smoking; alcohol drinking; smokeless tobacco;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Kerdpon, D Prince Songkla Univ, Fac Dent, Dept Stomatol, Hat Yai 90112, Songkhla, Thailand Prince Songkla Univ Hat Yai Songkhla Thailand 90112 , Thailand
Citazione:
D. Kerdpon et al., "Expression of p53 in oral squamous cell carcinoma and its association withrisk habits in southern Thailand", ORAL ONCOL, 37(7), 2001, pp. 553-557

Abstract

Tobacco smoking and alcohol drinking are the principal factors associated with p53 expression in oral squamous cell carcinomas (OSCC) in the west, whereas betel quid chewing and smokless tobacco are important factors in the east. Variable results of p53 expression have been reported and it has beenproposed that ethnic difference and a variation in the indigenous oral habit may be responsible for the finding. This study, therefore, investigated p53 expression among 106 OSCC patients from a southern Thailand population in which all four risk behaviours, tobacco smoking, alcohol drinking, betelquid chewing and use of smokless tobacco, are practised. The associations of p53 expression with lifetime exposure to each risk behaviour were explored. Multivariate modelling showed that lifetime exposure to alcohol drinking was significantly positively associated with p53 expression (likelihood ratio P value 0.01). Betel quid chewing and tobacco smoking habit showed a trend of decreasing risk of p53 expression with increased lifetime exposure (OR 0.62, 95% CI 0.39-1.00 and OR 0.50, 95% CI 0.26-0.98, respectively). Nosignificant association was found between p53 expression and clinico-pathological parameters. Further investigations are needed to study (1) the molecular alteration of p53 in each risk habit and (2) other possible pathways of oral carcinogenesis in betel quid- and tobacco smoking-associated OSCC in these group of patients. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 12:38:23