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Titolo:
Modeling Philadelphia chromosome positive leukemias
Autore:
Wong, S; Witte, ON;
Indirizzi:
Univ Calif Los Angeles, Howard Hughes Med Inst, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Univ Calif Los Angeles, Dept Microbiol Mol Genet & Immunol, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Univ Calif Los Angeles, Inst Mol Biol, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA
Titolo Testata:
ONCOGENE
fascicolo: 40, volume: 20, anno: 2001,
pagine: 5644 - 5659
SICI:
0950-9232(20010910)20:40<5644:MPCPL>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC MYELOGENOUS LEUKEMIA; CHRONIC MYELOID-LEUKEMIA; ACUTE LYMPHOBLASTIC-LEUKEMIA; ABL TYROSINE KINASE; P210 BCR-ABL; SEQUENCE-BINDING-PROTEIN; GROWTH-FACTOR INDEPENDENCE; VIRUS TRANSFORMING PROTEIN; COLONY-STIMULATING FACTOR; HEMATOPOIETIC STEM-CELLS;
Keywords:
BCR-ABL; mouse model; leukemia;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
152
Recensione:
Indirizzi per estratti:
Indirizzo: Witte, ON Univ Calif Los Angeles, Howard Hughes Med Inst, 675 Charles E Young Dr S,Room 5-748 MRL Bldg, Los Angeles, CA 90095 USA Univ Calif Los Angeles 675 Charles E Young Dr S,Room 5-748 MRL Bldg Los Angeles CA USA 90095
Citazione:
S. Wong e O.N. Witte, "Modeling Philadelphia chromosome positive leukemias", ONCOGENE, 20(40), 2001, pp. 5644-5659

Abstract

The Ph chromosome has been genetically linked to CML and ALL. Its chimericfusion gene product, BCR-ABL, can generate leukemia in mice. This review will discuss selected model systems developed to study BCR-ABL induced leukemia and focuses on what we have learned about the human disease from these models. Five main experimental approaches will be discussed including: (i) Reconstitution of mice with bone marrow cells retrovirally transduced with BCR-ABL; (ii) Transgenic mice expressing BCR-ABL; (iii) Knock-in mice with BCR-ABL expression driven from the endogenous ber locus; (iv) Development of CML-like disease in mice with loss of function mutations in heterologous genes; and (v) ES in vitro hematopoietic differentiation coupled with regulated BCR-ABL expression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 08:45:01