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Titolo:
The role of TCL1 in human T-cell leukemia
Autore:
Pekarsky, Y; Hallas, C; Croce, CM;
Indirizzi:
Thomas Jefferson Univ, Kimmerl Canc Ctr, Philadelphia, PA 19107 USA ThomasJefferson Univ Philadelphia PA USA 19107 hiladelphia, PA 19107 USA
Titolo Testata:
ONCOGENE
fascicolo: 40, volume: 20, anno: 2001,
pagine: 5638 - 5643
SICI:
0950-9232(20010910)20:40<5638:TROTIH>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR NGFI-B; ATAXIA-TELANGIECTASIA; CHROMOSOME TRANSLOCATIONS; PROLYMPHOCYTIC LEUKEMIA; BURKITT-LYMPHOMA; TRANSGENIC MICE; GENE; EXPRESSION; KINASE; PHOSPHORYLATION;
Keywords:
14q32.1; TCLI; TCLIb; Akt; T-cell leukemia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Croce, CM Thomas Jefferson Univ, Kimmerl Canc Ctr, 233 S 10th St,BLSB Room1050, Philadelphia, PA 19107 USA Thomas Jefferson Univ 233 S 10th St,BLSB Room 1050 Philadelphia PA USA 19107
Citazione:
Y. Pekarsky et al., "The role of TCL1 in human T-cell leukemia", ONCOGENE, 20(40), 2001, pp. 5638-5643

Abstract

The TCL1 locus on human chromosome 14q32.1 is activated in T-cell leukemias by translocations and inversions that juxtapose it to regulatory elementsof T-cell receptor genes. We isolated and characterized four genes at thislocus, TCL1 and TCL1b (T-cell leukemia/lymphoma 1 and 1b), and TNG1 and TNG2 (TCL neighboring genes 1 and 2) all of which are overexpressed followingrearrangements involving 14q32.1. TCL1 and TCL1b show 60% similarity and are represented in the mouse by a cluster of six homologous genes. In humansTCL1 and TCL1b show similar expression patterns: They are expressed mainlyin CD4-/CD8- immature T-cells, pre B-cells and virgin B-cells. Expression decreases significantly at more mature stages of B-cell development. Activation of TCL1 and/or TCL1b in mature T-cells causes T-cell leukemia in humans. The oncogenic nature of TCL1 was confirmed by the analysis of a transgenic mouse model. Functional analysis of Tcl1 revealed its involvement in a P13-kinase dependent Akt (PKB) pro-survival pathway through its interaction with the Akt kinase which increases Akt's enzymatic activity and promotes translocation of Akt to the nucleus.

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Documento generato il 20/09/20 alle ore 07:31:42