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Titolo:
Iron concentrations and distributions in the parkinsonian substantia nigraof aged and young primate models
Autore:
Ren, MQ; Xie, JP; Wang, XS; Ong, WY; Leong, SK; Watt, F;
Indirizzi:
Natl Univ Singapore, Dept Phys, Res Ctr Nucl Microscopy, Singapore 119260,Singapore Natl Univ Singapore Singapore Singapore 119260 ingapore 119260,Singapore Natl Univ Singapore, Dept Anat, Singapore 119260, Singapore Natl Univ Singapore Singapore Singapore 119260 ngapore 119260, Singapore
Titolo Testata:
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS
, volume: 181, anno: 2001,
pagine: 522 - 528
SICI:
0168-583X(200107)181:<522:ICADIT>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELEMENTAL CHANGES; DISEASE; RAT; LOCALIZATION; MICROSCOPY; BRAIN;
Keywords:
MPTP; Parkinson's disease; iron granules; nuclear microscopy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Engineering, Computing & Technology
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Watt, F Natl Univ Singapore, Dept Phys, Res Ctr Nucl Microscopy, 10 Kent Ridge Crescent, Singapore 119260, Singapore Natl Univ Singapore 10 Kent Ridge Crescent Singapore Singapore 119260
Citazione:
M.Q. Ren et al., "Iron concentrations and distributions in the parkinsonian substantia nigraof aged and young primate models", NUCL INST B, 181, 2001, pp. 522-528

Abstract

Parkinson's disease (PD) is a progressive neuronal degenerative brain disease of the elderly, and is caused by the selective degeneration of neurons in the substantia nigra (SN) region of the brain, resulting in a reduced production of the neurotransmitter dopamine. Iron has been linked to dopaminergic cell death in Parkinson's disease because of its potential to promote free radicals, leading to oxidative stress. The present study is aimed at using the techniques of nuclear microscopy to elucidate the iron concentrations and distributions in the SN of both young and old monkeys following unilateral 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioning. A group of three old monkeys (older than 7 years) and a group of three young monkeys (younger than 7 years) were unilaterally MPTP-lesioned (right side) to induce parkinsonism and sacrificed after 35 days. The left side SN was used as a control. This time interval was chosen to correspond to an average 50% loss of dopamine producing cells in the lesioned right side SN, Wehave observed a significant difference in iron concentrations between the SNs of the young and old monkeys (increasing from an average of 233 to 1092parts per million dry weight). When comparing the lesioned and non-lesioned SNs of the same animal, we found no significant difference in iron levelsfor each young monkey. However we have found a slight increase in iron (approximately 10%) between the lesioned SN and control SN for old monkeys. Wehave also observed that in the SN of younger primates, there is a weak anti-correlation in the SN iron levels with the neuron distribution. In the older monkeys, however, we have observed a proliferation of iron-rich granules, which appear to be more strongly anti-correlated with the distribution of neurons. The iron-cell anti-correlation occurs both in the control as well as the lesioned SN. Our results suggest that iron, particularly in the form of iron-rich deposits, accumulates in specific sites in the SN with age. Since Parkinson's disease mainly occurs in the elderly, this may implicateiron as a factor in dopaminergic cell death through iron-catalysed free radical production. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 28/03/20 alle ore 14:05:32