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Titolo:
Expression of Schwann cell-specific proteins and low-molecular-weight neurofilament protein during regeneration of sciatic nerve treated with neurotrophin-4
Autore:
Yin, Q; Kemp, GJ; Yu, LG; Wagstaff, SC; Frostick, SP;
Indirizzi:
Univ Liverpool, Dept Musculoskeletal Sci, Liverpool L69 3GA, Merseyside, England Univ Liverpool Liverpool Merseyside England L69 3GA , Merseyside, England Univ Liverpool, Dept Med, Liverpool L69 3GA, Merseyside, England Univ Liverpool Liverpool Merseyside England L69 3GA , Merseyside, England Univ Liverpool, Dept Human Anat & Cell Biol, Liverpool L69 3GE, Merseyside, England Univ Liverpool Liverpool Merseyside England L69 3GE , Merseyside, England
Titolo Testata:
NEUROSCIENCE
fascicolo: 3, volume: 105, anno: 2001,
pagine: 779 - 783
SICI:
0306-4522(2001)105:3<779:EOSCPA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYELIN-ASSOCIATED GLYCOPROTEIN; PERIPHERAL-NERVE; ADHESION MOLECULES; MESSENGER-RNAS; BASIC-PROTEIN; NEURONS; TRANSPORT; RECOVERY; FIBERS; REPAIR;
Keywords:
myelin-associated glycoprotein; myelin basic protein; low-molecular-weight neurofilament; peripheral nerve regeneration;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Yin, Q Univ Liverpool, Dept Musculoskeletal Sci, Liverpool L69 3GA, Merseyside, England Univ Liverpool Liverpool Merseyside England L69 3GA yside, England
Citazione:
Q. Yin et al., "Expression of Schwann cell-specific proteins and low-molecular-weight neurofilament protein during regeneration of sciatic nerve treated with neurotrophin-4", NEUROSCIENC, 105(3), 2001, pp. 779-783

Abstract

Neurotrophin-4 acts as a potent survival factor for subpopulations of motoneurons. To investigate its effect on Schwann cell sheath and axonal proteins during peripheral nerve regeneration, sciatic nerves in adult rats were transected and repaired, and fibrin glue containing neurotrophin-4 injectedaround the repair site. At 5, 15, 30 and 60 days after repair, 5-mm nerve segments distal to the repair were collected, and western blotting was usedto measure myelin-associated glycoprotein, myelin basic protein and low-molecular-weight neurofilament protein. In control groups these dramatically declined at 5 and 15 days then increased from 30 and 60 days. However, in the neurotrophin-4 group there was a significant increase (to several times basal values) in myelin-associated glycoprotein and myelin basic protein at5-15 days. The relatively small increases (<7%) in Schwann cell numbers suggest that this is mainly due to increased synthesis per cell. The neurotrophin-4 group also showed a small but significant increase at 15 days in low-molecular-weight neurofilament protein, which however remained much lower than basal. We conclude that neurotrophin-4 regulates the expression of myelin-associated glycoprotein, myelin basic protein, and to a lesser extent low-molecular-weight neurofilament protein, during peripheral nerve regeneration. (C) 2001 IBRO. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 01:08:41