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Titolo:
Spontaneous circling behavior and dopamine neuron loss in a genetically hypothyroid mouse
Autore:
Kincaid, AE;
Indirizzi:
Creighton Univ, Dept Phys Therapy, Omaha, NE 68178 USA Creighton Univ Omaha NE USA 68178 Dept Phys Therapy, Omaha, NE 68178 USA Creighton Univ, Dept Biomed Sci, Omaha, NE 68178 USA Creighton Univ OmahaNE USA 68178 v, Dept Biomed Sci, Omaha, NE 68178 USA
Titolo Testata:
NEUROSCIENCE
fascicolo: 4, volume: 105, anno: 2001,
pagine: 891 - 898
SICI:
0306-4522(2001)105:4<891:SCBADN>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSGENIC INSERTIONAL MUTANT; HYT/HYT MOUSE; CONGENITAL HYPOTHYROIDISM; THYROID-HORMONES; OPTIC-NERVE; NORMAL RATS; HYT MICE; DYSFUNCTION; MUTATION; SYSTEM;
Keywords:
stereology; substantia nigra; ventral tegmental area; tyrosine hydroxylase; asymmetry; thyroxine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Kincaid, AE Creighton Univ, Dept Phys Therapy, 2500 Calif Plaza, Omaha, NE68178 USA Creighton Univ 2500 Calif Plaza Omaha NE USA 68178 E 68178 USA
Citazione:
A.E. Kincaid, "Spontaneous circling behavior and dopamine neuron loss in a genetically hypothyroid mouse", NEUROSCIENC, 105(4), 2001, pp. 891-898

Abstract

The genetically hypothyroid mouse, Tshr(hyt), has a single point mutation resulting in a defective thyroid-stimulating hormone receptor, and therefore a non-functional thyroid gland. This is an autosomal recessive disorder and affected mice have been reported to have a number of somatic and behavioral deficits. This study reports a pronounced, spontaneous, asymmetrical circling behavior in the Tshr(hyt) mouse. The spontaneous circling behavior appeared in about 25% of the homozygous animals, in both males and females. The circling usually appeared by postnatal day 35 and continued throughout the lifespan of the animal. The circling was in one direction only, either clockwise or counterclockwise, with the directional preference being almostabsolute. A stereological analysis of tyrosine hydroxylase immunoreactive neurons in the substantia nigra and adjacent ventral tegmental area of circling homozygous mice, non-circling homozygous mice and heterozygous mice revealed that the circlers had significantly fewer (40% reduction) midbrain dopamine neurons than those animals that did not circle. There was not an association between the direction of the circling and an asymmetry in the number of dopamine neurons in the midbrains of these mice. There was no difference in the number of dopamine neurons in the midbrain of the homozygous non-circlers and the heterozygous mice. These studies indicate that about 25% of genetically hypothyroid mice demonstrated a spontaneous, perseverative, unilateral circling behavior that was associated with a significant reduction in the number of their midbrain dopamine neurons. Thus congenitally hypothyroid mice are at risk for a reduction in the number of nigral dopamine neurons and an associated repetitive movement disorder. (C) 2001 IBRO. Published by Elsevier Science Ltd. All rights reserved.

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Documento generato il 01/04/20 alle ore 09:54:39