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Titolo:
Neostriatal and globus pallidus stimulation induced inhibitory postsynaptic potentials in entopeduncular neurons in rat brain slice preparations
Autore:
Kita, H;
Indirizzi:
Univ Tennessee, Dept Anat & Neurobiol, Memphis, TN 38163 USA Univ Tennessee Memphis TN USA 38163 at & Neurobiol, Memphis, TN 38163 USA
Titolo Testata:
NEUROSCIENCE
fascicolo: 4, volume: 105, anno: 2001,
pagine: 871 - 879
SICI:
0306-4522(2001)105:4<871:NAGPSI>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELECTRICAL MEMBRANE-PROPERTIES; NIGRA PARS RETICULATA; SUBTHALAMIC NUCLEUS; BASAL GANGLIA; CORTICAL STIMULATION; PROJECTION NEURONS; EXTERNAL PALLIDUM; PHA-L; PRIMATES; PARKINSONISM;
Keywords:
neostriatum; globus pallidus; entopeduncular nucleus; intracellular recording; inhibitory postsynaptic responses; slice preparation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Kita, H Univ Tennessee, Dept Anat & Neurobiol, 855 Monroe Ave, Memphis, TN38163 USA Univ Tennessee 855 Monroe Ave Memphis TN USA 38163 s, TN 38163 USA
Citazione:
H. Kita, "Neostriatal and globus pallidus stimulation induced inhibitory postsynaptic potentials in entopeduncular neurons in rat brain slice preparations", NEUROSCIENC, 105(4), 2001, pp. 871-879

Abstract

Recent anatomical studies revealed that the entopeduncular nucleus of the rat receives GABAergic inputs from both the neostriatum and the globus pallidus. The present study was undertaken to reveal the physiological featuresof these inputs using the intracellular recording method in rat brain slice preparations. Most of the entopeduncular nucleus neurons generated repetitive firing without spike accommodation with intracellular current stimulation and thus were classified as Type-I. A small number of neurons were classified as Type-II since they generated spikes with pronounced accommodation. Most of the Type-I, but none of Type-II, entopeduncular nucleus neurons exhibited monosynaptic GABAergic inhibitory postsynaptic potentials (IPSPs) after stimulation of the neostriatum and the globus pallidus. Neostriatal stimulation induced long latency IPSPs while pallidal stimulation induced long latency IPSPs compounded with short latency IPSPs. The IPSPs were mediated by GABAA receptors. The unitary IPSPs to striatal stimulation were smallwhile those to pallidal stimulation were large in amplitude and able to reset ongoing rhythmic firing. The short latency IPSPs induced by pallidal stimulation reversed at a somatic membrane potential that was a few millivolts more depolarized than the long latency IPSPs, suggesting that the striatal inputs were evoked in more distal portions of the neurons than the pallidal inputs. Repetitive activation of these inputs resulted in a poor amplitude summation but a prolongation of the duration of the IPSPs. The results of the present study indicate that the pallidal projection to the entopeduncular nucleus is physiologically significant and that the neostriatum. and the globus pallidus play important roles in controlling the activity of the entopeduncular nucleus, although in different ways. (C) 2001 IBRO. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/06/19 alle ore 17:58:05