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Titolo:
Effect of LSD on prepulse inhibition and spontaneous behavior in the rat: A pharmacological analysis and comparison between two rat strains
Autore:
Ouagazzal, AM; Grottick, AJ; Moreau, JL; Higgins, GA;
Indirizzi:
F Hoffmann La Roche, Preclin Studies, Div Pharmaceut, Basel, Switzerland FHoffmann La Roche Basel Switzerland iv Pharmaceut, Basel, Switzerland
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 4, volume: 25, anno: 2001,
pagine: 565 - 575
SICI:
0893-133X(200110)25:4<565:EOLOPI>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
5-HT2C RECEPTOR ANTAGONIST; ACOUSTIC STARTLE REFLEX; HALLUCINOGENIC DRUGS; ANTIPSYCHOTIC-DRUGS; DOPAMINE-RECEPTOR; WISTAR RATS; AGONISTS; DOI; SEROTONIN; MDL-100,907;
Keywords:
5-HT2 receptor; PPI; LSD; hallucinogen;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Ouagazzal, AM Inst Genet & Biol Mol & Cellulaire, BP 163, F-67404 IllkirchGraffenstaden, France Inst Genet & Biol Mol & Cellulaire BP 163 Illkirch Graffenstaden France F-67404
Citazione:
A.M. Ouagazzal et al., "Effect of LSD on prepulse inhibition and spontaneous behavior in the rat: A pharmacological analysis and comparison between two rat strains", NEUROPSYCH, 25(4), 2001, pp. 565-575

Abstract

The goal of the present study was to better delineate the mechanisms of action of the prototypical hallucinogen LSD. LSD (0.03, 0.1 and 0.3 mg/kg, s.c.) produced locomotor hyperactivity, disruption of PPT and a number of behaviors indicative of 5-HT activation such as wet-dog shakes, back muscle contractions and forepaw treading. These various behavioral effects of LSD were studied in both Sprague-Dawley and Wistar rats, although with the exception of back muscle contractions which were more prominent in Sprague-Dawleyrats, no major strain dfferences were detected. The PPI disruption inducedby LSD (0.1 mg/kg) in Sprague-Dawley rats was completely reversed by pretreatment with the selective 5-HT2A antagonist MDL 100907 (0.5 and 1 mg/kg, s.c.). In contrast, pretreatment with antagonists at 5-HT2C, (SB 242084 (0.5mg/kg, i.p.)); 5-HT2B/2C (SDZ SER 082 (1 mg/kg, sx.)); 5-HT1A, ((+)-WAY 100135 (1 and 20 mg/kg s.c.)) and 5-HT6 receptors, (RO 04-6790 (30 mg/kg, i.p.)), all failed to influence LSD-induced disruption of PPI The dopamine DA(2like), receptor antagonist, haloperidol (0.1 and 0.2 mg/kg, s.c.), was without effect against an LSD-induced disruption of PPI. Finally, selective blockade of 5-HT A but not 5-HT2c receptors completely abolished the locomotor hyperactivity induced by LSD. These findings provide empirical evidence to support the view that the hallucinogenic effects of LSD are mediated Inj a direct agonist effect at 5-HT2A receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 18:59:23