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Titolo:
Comparative, topographically-based evaluation of behavioural phenotype andspecification of D-1-like: D-2 interactions in a line of incipient congenic mice with D-2 dopamine receptor "knockout"
Autore:
Clifford, JJ; Kinsella, A; Tighe, O; Rubinstein, M; Grandy, DK; Low, MJ; Croke, DT; Waddington, JL;
Indirizzi:
Royal Coll Surgeons Ireland, Dept Clin Pharmacol, Dublin 2, Ireland Royal Coll Surgeons Ireland Dublin Ireland 2 harmacol, Dublin 2, Ireland Royal Coll Surgeons Ireland, Dept Biochem, Dublin 2, Ireland Royal Coll Surgeons Ireland Dublin Ireland 2 Biochem, Dublin 2, Ireland Tralee Gen Hosp, Dept Biochem, Tralee, Ireland Tralee Gen Hosp Tralee Ireland Gen Hosp, Dept Biochem, Tralee, Ireland Dublin Inst Technol, Dept Math, Dublin, Ireland Dublin Inst Technol Dublin Ireland Technol, Dept Math, Dublin, Ireland Univ Buenos Aires, Inst Invest Ingn Genet & Biol Mol, Buenos Aires, DF, Argentina Univ Buenos Aires Buenos Aires DF Argentina Buenos Aires, DF, Argentina Oregon Hlth Sci Univ, Vollum Inst, Portland, OR 97201 USA Oregon Hlth Sci Univ Portland OR USA 97201 m Inst, Portland, OR 97201 USA Oregon Hlth Sci Univ, Dept Physiol & Pharmacol, Portland, OR 97201 USA Oregon Hlth Sci Univ Portland OR USA 97201 rmacol, Portland, OR 97201 USA
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 4, volume: 25, anno: 2001,
pagine: 527 - 536
SICI:
0893-133X(200110)25:4<527:CTEOBP>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
TARGETED GENE DELETION; WILD-TYPE MICE; DEFICIENT MICE; MUTANT MICE; AUTORECEPTOR FUNCTION; LOCOMOTOR-ACTIVITY; D2 RECEPTORS; OUT MICE; AGONISTS; LACKING;
Keywords:
dopamine D-2 receptor; D-2 'knockout'; targeted gene deletion; behavioural phenotype; topographical assessment; ethogram;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Waddington, JL Royal Coll Surgeons Ireland, Dept Clin Pharmacol, St Stephens Green, Dublin 2, Ireland Royal Coll Surgeons Ireland St Stephens Green Dublin Ireland 2
Citazione:
J.J. Clifford et al., "Comparative, topographically-based evaluation of behavioural phenotype andspecification of D-1-like: D-2 interactions in a line of incipient congenic mice with D-2 dopamine receptor "knockout"", NEUROPSYCH, 25(4), 2001, pp. 527-536

Abstract

Phenotypes were assessed topographically in mice lacking functional D-2 dopamine receptors [knockouts], using an ethologically based approach to assess all behaviours in the natural repertoire, D-2-null mice evidenced an ethogram characterised initially by modest reductions in locomotion and shiftsin rearing topographies. Subsequently, topographies of behaviour habituated similarly for wildtypes and 'knockouts'. Following challenge with the D-2-like agonist RU 24213, both inhibition of rearing at a lower dose and induction of stereotyped sniffing and ponderous locomotion at higher doses wereessentially absent in D-2-null mice. Following challenge with the D-1-likeagonist A 68930, vacuous chewing was released in D-2-null mice. This topographical approach to phenotypic characterisation implicates: (i) the D-2 receptor in these D-2-like agonist effects and in oppositional D-1-like: D-2-like interactions; and (ii) the operation of material compensatory processes consequent to the developmental absence of D-2 receptors which are able to maintain ethological function under tonic, 'naturalistic' conditions but not under 'phasic' challenge.

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Documento generato il 02/04/20 alle ore 12:30:47