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Titolo:
Changes in muscle tone are regulated by D1 and D2 dopamine receptors in the ventral striatum and D1 receptors in the substantia nigra
Autore:
Hemsley, KM; Crocker, AD;
Indirizzi:
Flinders Univ S Australia, Ctr Neurosci, Dept Clin Pharmacol, Bedford Pk, SA 5042, Australia Flinders Univ S Australia Bedford Pk SA Australia 5042 SA 5042, Australia
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 4, volume: 25, anno: 2001,
pagine: 514 - 526
SICI:
0893-133X(200110)25:4<514:CIMTAR>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
BASAL GANGLIA; SCHIZOPHRENIC-PATIENTS; ANTIPSYCHOTIC-DRUGS; JAW MOVEMENTS; MOTOR CORTEX; SCH 23390; RAT-BRAIN; IN-VIVO; ANTAGONIST; D-1;
Keywords:
muscle rigidity; extrapyramidal side effects; dopamine receptors; antipsychotic drugs; ventral striatum; substantia nigra;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
71
Recensione:
Indirizzi per estratti:
Indirizzo: Crocker, AD Flinders Univ S Australia, Ctr Neurosci, Dept Clin Pharmacol, Bedford Pk, SA 5042, Australia Flinders Univ S Australia Bedford Pk SA Australia 5042 tralia
Citazione:
K.M. Hemsley e A.D. Crocker, "Changes in muscle tone are regulated by D1 and D2 dopamine receptors in the ventral striatum and D1 receptors in the substantia nigra", NEUROPSYCH, 25(4), 2001, pp. 514-526

Abstract

Muscle rigidity associated with antipsychotic drug treatment is believed to result from reduced striatal dopamine neurotransmission. In the current study the regulatory roles of dopamine D1 and D2 receptor subfamilies in thedorsal (DSTR) and ventral striatum. (VSTR) and substantia nigra (SN) were investigated on muscle tone, assessed as increases in tonic electromyographic (EMG) activity. Rats were injected with the irreversible D1/D2 antagonist N-ethoxycarbonyl-2ethoxy-1,2-dihydroquinoline (EEDQ), the reversible DI antagonist SCH23390, or D2 antagonist sulpiride. Increased EMG activity was observed following injection of EEDQ and SCH23390 into the SN or VSTR, and sulpiride into the VSTR. Mapping, using quantitative autoradiographic analysis of dopamine receptor occupancy after striatal injections, showed D1 andD2 receptors in discrete ventral sites were associated with EMG increases. Overall the results support roles for dopamine D1 and D2 receptors in the ventral striation, and D1 receptors in the substantia nigra, in the regulation of muscle tone.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/11/19 alle ore 02:28:49