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Titolo:
Effects of haloperidol on selective attention - A combined whole-head MEG and high-resolution EEG study
Autore:
Kahkonen, S; Ahveninen, J; Jaaskelainen, IP; Kaakkola, S; Naatanen, R; Huttunen, J; Pekkonen, E;
Indirizzi:
Univ Helsinki, Cent Hosp, Med Engn Ctr, BioMag Lab, FIN-00029 HUS, FinlandUniv Helsinki HUS Finland FIN-00029 , BioMag Lab, FIN-00029 HUS, Finland Univ Helsinki, Dept Psychol, Cognit Brain Res Unit, SF-00100 Helsinki, Finland Univ Helsinki Helsinki Finland SF-00100 Unit, SF-00100 Helsinki, Finland Univ Helsinki, Cent Hosp, Dept Neurol, Helsinki, Finland Univ Helsinki Helsinki Finland ent Hosp, Dept Neurol, Helsinki, Finland Univ Helsinki, Cent Hosp, Dept Clin Neurophysiol, Helsinki, Finland Univ Helsinki Helsinki Finland ept Clin Neurophysiol, Helsinki, Finland Harvard Univ, Sch Med, Massachusetts Gen Hosp, NMR Ctr, Charlestown, MA USA Harvard Univ Charlestown MA USA s Gen Hosp, NMR Ctr, Charlestown, MA USA
Titolo Testata:
NEUROPSYCHOPHARMACOLOGY
fascicolo: 4, volume: 25, anno: 2001,
pagine: 498 - 504
SICI:
0893-133X(200110)25:4<498:EOHOSA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
MISMATCH NEGATIVITY; PROCESSING NEGATIVITY; AUDITORY ATTENTION; HUMAN-BRAIN; RECEPTORS; MODULATION; TRANSMISSION; SUPPRESSION; VOLUNTEERS; DOPAMINE;
Keywords:
auditory; D2 receptors; electroencephalography (EEG); haloperidol; magnetoencephalography (MEG); selective attention;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Kahkonen, S Univ Helsinki, Cent Hosp, Med Engn Ctr, BioMag Lab, POB 340, FIN-00029 HUS, Finland Univ Helsinki POB 340 HUS Finland FIN-00029 0029 HUS, Finland
Citazione:
S. Kahkonen et al., "Effects of haloperidol on selective attention - A combined whole-head MEG and high-resolution EEG study", NEUROPSYCH, 25(4), 2001, pp. 498-504

Abstract

We used 122-channel magnetoencephalography (MEG) and 64-channel electroencephalogrphy (EEG) simultaneously to study the effects of dopaminergic transmission on human selective attention in a randomized, double-blind placebo-controlled cross-over design. A single dose of dopamine D2 receptor antagonist haloperidol (2 mg) or placebo was given orally to 12 right-handed healthy volunteers 3 hours before measurement. In a dichotic selective attentiontask, subjects were presented with two trains of standard (700 Hz to the left ear, 1,100 Hz to the right ear) and deviant (770 and 1,210 Hz, respectively) tones. Subjects were instructed to count the tones presented to one ear; whereas, the tones presented to the other ear were to be ignored. Haloperidol significantly attenuated processing negativity (PN), an event-related potential (ERP) component elicited by selectively attended standard tonesat 300-500 ins after stimulus presentation. These results, indicating impaired selective attention by a blockade of dopamine D2 receptors, were further accompanied with increased mismatch negativity (MMN), elicited by involuntary detection of task-irrelevant deviants. Taken together, haloperidol seemed to induce functional changes in neural networks accounting for both selective and involuntary attention, suggesting modulation of these functionsby dopamine D2 receptors.

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Documento generato il 24/01/20 alle ore 16:30:14