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Titolo:
In vivo characterization of basal amino acid levels in subregions of the rat nucleus accumbens: effect of a dopamine D-3/D-2 agonist
Autore:
Hemmati, P; Shilliam, CS; Hughes, ZA; Shah, AJ; Roberts, JC; Atkins, AR; Hunter, AJ; Heidbreder, CA;
Indirizzi:
GlaxoSmithKline Pharmaceut, Neurosci Res, Harlow CM19 5AW, Essex, England GlaxoSmithKline Pharmaceut Harlow Essex England CM19 5AW , Essex, England GlaxoSmithKline Pharmaceut, Computat & Struct Sci Mass Spectrometry, Harlow CM19 5AW, Essex, England GlaxoSmithKline Pharmaceut Harlow Essex EnglandCM19 5AW , Essex, England
Titolo Testata:
NEUROCHEMISTRY INTERNATIONAL
fascicolo: 3, volume: 39, anno: 2001,
pagine: 199 - 208
SICI:
0197-0186(200109)39:3<199:IVCOBA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
ULTRASTRUCTURAL IMMUNOCYTOCHEMICAL LOCALIZATION; NITRIC-OXIDE; EXTRACELLULAR DOPAMINE; RECEPTOR STIMULATION; SHELL SUBTERRITORIES; GABAERGIC NEURONS; PREFRONTAL CORTEX; VENTRAL STRIATUM; MESSENGER-RNA; GABA RELEASE;
Keywords:
amino acids; core; microdialysis; nucleus accumbens; quinelorane; shell;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Heidbreder, CA GlaxoSmithKline Pharmaceut, Neurosci Res, New Frontiers SciPk N, Harlow CM19 5AW, Essex, England GlaxoSmithKline Pharmaceut New Frontiers Sci Pk N Harlow Essex England CM19 5AW
Citazione:
P. Hemmati et al., "In vivo characterization of basal amino acid levels in subregions of the rat nucleus accumbens: effect of a dopamine D-3/D-2 agonist", NEUROCHEM I, 39(3), 2001, pp. 199-208

Abstract

Recent evidence demonstrates that two subdivisions of the nucleus accumbens, the dorsolateral core and the ventromedial shell can be distinguished bymorphological, immunohistochemical and chemoarchitectural differences. In the present study, we measured basal levels of amino acids in microdialysates from both the shell and core subterritories of the nucleus accumbens in freely moving rats using HPLC with fluorescence detection. The effect of the dopamine D-3/D-2 receptor agonist quinelorane (30 mug/kg s.c.) was then investigated in both subregions. With the exception of glutamate, histidine,and serine, which showed similar levels in both subterritories, alanine, arginine, aspartate, gamma -aminobutyric acid, glutamine, and tyrosine were significantly higher in the shell compared with the core. In contrast, taurine levels were significantly lower in the shell than in the core. A particularly striking difference across subregions of the nucleus accumbens was observed for basal GABA levels with a shell/core ratio of 18.5. Among all the amino acids investigated in the present study, quinelorane selectively decreased dialysate GABA levels in the core subregion of the nucleus accumbens. The results of the present study point to specific profiles of both shell and core in terms of(1) basal chemical neuroanatomical markers for amino acids; and (2) GABAergic response to the DA D-3/D-2 agonist quinelorane. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 12:16:32