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Titolo:
Distribution of serotonin, its metabolites and 5-HT transporters in the neostriatum of Lurcher and weaver mutant mice
Autore:
Reader, TA; Hebert, C; Ase, AR; Le Marec, N;
Indirizzi:
Univ Montreal, Fac Med, Dept Physiol, Ctr Rech Sci Neurol, Montreal, PQ H3C 3J7, Canada Univ Montreal Montreal PQ Canada H3C 3J7 ol, Montreal, PQ H3C 3J7, Canada Hotel Dieu, Ctr Rech, Unite Neurol Comportement Neurobiol & Neuropsycho, Montreal, PQ H2T 1W8, Canada Hotel Dieu Montreal PQ Canada H2T 1W8 sycho, Montreal, PQ H2T 1W8, Canada Hop Sacre Coeur, Ctr Rech, Montreal, PQ H4J 1C5, Canada Hop Sacre Coeur Montreal PQ Canada H4J 1C5 , Montreal, PQ H4J 1C5, Canada
Titolo Testata:
NEUROCHEMISTRY INTERNATIONAL
fascicolo: 3, volume: 39, anno: 2001,
pagine: 169 - 177
SICI:
0197-0186(200109)39:3<169:DOSIMA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADULT-RAT NEOSTRIATUM; NEONATAL 6-HYDROXYDOPAMINE LESION; ORAL ACTIVITY RESPONSES; K+ CHANNEL GIRK2; DOPAMINE NEURONS; QUANTITATIVE AUTORADIOGRAPHY; PARKINSONS-DISEASE; VENTRAL MIDBRAIN; BRAIN DOPAMINE; D-2 RECEPTORS;
Keywords:
citalopram; HPLC; 5-hydroxyindole-3-acetic acid; 5-hydroxytryptophol; ataxia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: Reader, TA Univ Montreal, Fac Med, Dept Physiol, Ctr Rech Sci Neurol, CP6128 Succursale Ctr Ville, Montreal, PQ H3C 3J7, Canada Univ Montreal CP6128 Succursale Ctr Ville Montreal PQ Canada H3C 3J7
Citazione:
T.A. Reader et al., "Distribution of serotonin, its metabolites and 5-HT transporters in the neostriatum of Lurcher and weaver mutant mice", NEUROCHEM I, 39(3), 2001, pp. 169-177

Abstract

Serotonin (5-HT) uptake sites. or transporters, were measured in the neostriatum (caudate putamen) of wild type (+/+) mice and heterozygous (wv/+) and homozygous (wv/wv) weaver, as well as in heterozygous Lurcher (Lc/+) mutants. These topological surveys were carried out by quantitative ligand binding autoradiography using the uptake site antagonist [H-3]-citalopram as a probe of innervation densities in four quadrants of the rostral neostriatumand in two halves of the caudal neostriatum. In addition, tissue concentrations of 5-HT, 5-hydroxyindole-3-acetic acid and 5-hydroxytryptophol were measured by high-performance liquid chromatography with electrochemical detection in these neostriatal divisions. In +/+ mice and in Lc/+ mutants therewas a dorso-ventral gradient of increasing 5-HT levels, and they exhibiteda similar heterogeneity of [H-3]-citalopram labeling. In contrast, the gradients of 5-HT concentrations and [H-3]-citalopram binding disappeared in the weaver mutants, suggesting a rearrangement of the 5-HT innervation. Thisreorganization of the 5-HT system in the neostriatum was more obvious in the wv/wv and is compatible with the hypothesis that the postnatal dopaminergic deficiencies that characterize weaver mutants lead to a sprouting of fibers and thus constitute a genetic model of dopaminergic denervation that leads to a 5-HT hyperinnervation. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 04:04:35