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Titolo:
Desmosomal adhesion regulates epithelial morphogenesis and cell positioning
Autore:
Runswick, SK; OHare, MJ; Jones, L; Streuli, CH; Garrod, DR;
Indirizzi:
Univ Manchester, Sch Biol Sci, Manchester M13 9PT, Lancs, England Univ Manchester Manchester Lancs England M13 9PT M13 9PT, Lancs, England UCL, LICR, Breast Canc Lab, London W1W 4EJ, England UCL London England W1W 4EJ ICR, Breast Canc Lab, London W1W 4EJ, England Univ Leicester, Dept Pathol, Leicester LE2 7LX, Leics, England Univ Leicester Leicester Leics England LE2 7LX er LE2 7LX, Leics, England
Titolo Testata:
NATURE CELL BIOLOGY
fascicolo: 9, volume: 3, anno: 2001,
pagine: 823 - 830
SICI:
1465-7392(200109)3:9<823:DAREMA>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
PEMPHIGUS-VULGARIS ANTIGEN; EMBRYONIC HEART; N-CADHERIN; EXPRESSION; MOUSE; PLAKOGLOBIN; DESMOCOLLIN; GENE; DIFFERENTIATION; DESMOGLEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Garrod, DR Univ Manchester, Sch Biol Sci, 3-239 Stopford Bldg,Oxford Rd, Manchester M13 9PT, Lancs, England Univ Manchester 3-239 Stopford Bldg,Oxford Rd Manchester Lancs England M13 9PT
Citazione:
S.K. Runswick et al., "Desmosomal adhesion regulates epithelial morphogenesis and cell positioning", NAT CELL BI, 3(9), 2001, pp. 823-830

Abstract

Desmosomes are intercellular junctions of epithelia and are of widespread importance in the maintenance of tissue architecture. We provide evidence that desmosomal adhesion has a function in epithelial morphogenesis and cell-type-specific positioning. Blocking peptides corresponding to the cell adhesion recognition (CAR) sites of desmosomal cadherins block alveolar morphogenesis by epithelial cells from mammary lumen. Desmosomal CAR-site peptides also disrupt positional sorting of luminal and myoepithelial cells in aggregates formed by the reassociation of isolated cells. We demonstrate that desmosomal cadherins and E-cadherin are comparably involved in epithelial morphoregulation. The results indicate a wider role for desmosomal adhesion in morphogenesis than has previously been considered.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 22:28:18