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Titolo:
Isolation of multipotent adult stem cells from the dermis of mammalian skin
Autore:
Toma, JG; Akhavan, M; Fernandes, KJL; Barnabe-Heider, F; Sadikot, A; Kaplan, DR; Miller, FD;
Indirizzi:
McGill Univ, Montreal Neurol Inst, Ctr Neuronal Survival, Montreal, PQ H3A2B4, Canada McGill Univ Montreal PQ Canada H3A 2B4 vival, Montreal, PQ H3A2B4, Canada McGill Univ, Montreal Neurol Inst, Brain Tumor Res Ctr, Montreal, PQ H3A 2B4, Canada McGill Univ Montreal PQ Canada H3A 2B4 Ctr, Montreal, PQ H3A 2B4, Canada McGill Univ, Montreal Neurol Inst, Div Neurosurg, Montreal, PQ H3A 2B4, Canada McGill Univ Montreal PQ Canada H3A 2B4 surg, Montreal, PQ H3A 2B4, Canada
Titolo Testata:
NATURE CELL BIOLOGY
fascicolo: 9, volume: 3, anno: 2001,
pagine: 778 - 784
SICI:
1465-7392(200109)3:9<778:IOMASC>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
MARROW STROMAL CELLS; CENTRAL-NERVOUS-SYSTEM; BONE-MARROW; IN-VIVO; PROGENITOR CELLS; NEURONS; RAT; EXPRESSION; BRAIN; DIFFERENTIATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Toma, JG McGill Univ, Montreal Neurol Inst, Ctr Neuronal Survival, 3801 Rue Univ, Montreal, PQ H3A 2B4, Canada McGill Univ 3801 Rue Univ Montreal PQ Canada H3A 2B4 2B4, Canada
Citazione:
J.G. Toma et al., "Isolation of multipotent adult stem cells from the dermis of mammalian skin", NAT CELL BI, 3(9), 2001, pp. 778-784

Abstract

We describe here the isolation of stem cells from juvenile and adult rodent skin. These cells derive from the dermis, and clones of individual cells can proliferate and differentiate in culture to produce neurons, glia, smooth muscle cells and adipocytes. Similar precursors that produce neuron-specific proteins upon differentiation can be isolated from adult human scalp. Because these cells (termed SKPs for skin-derived precursors) generate bothneural and mesodermal progeny, we propose that they represent a novel multipotent adult stem cell and suggest that skin may provide an accessible, autologous source of stem cells for transplantation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 06:55:35