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Titolo:
Orchestrating anaphase and mitotic exit: separase cleavage and localization of Slk19
Autore:
Sullivan, M; Lehane, C; Uhlmann, F;
Indirizzi:
Imperial Canc Res Fund, Chromosome Segregat Lab, London WC2A 3PX, England Imperial Canc Res Fund London England WC2A 3PX London WC2A 3PX, England
Titolo Testata:
NATURE CELL BIOLOGY
fascicolo: 9, volume: 3, anno: 2001,
pagine: 771 - 777
SICI:
1465-7392(200109)3:9<771:OAAMES>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
YEAST SACCHAROMYCES-CEREVISIAE; SISTER-CHROMATID SEPARATION; CHROMOSOME; COHESIN; SPINDLE; GENES; PROTEOLYSIS; METAPHASE; MOVEMENT; PROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Uhlmann, F Imperial Canc Res Fund, Chromosome Segregat Lab, 44 Lincolns Inn Fields, London WC2A 3PX, England Imperial Canc Res Fund 44 Lincolns Inn Fields London England WC2A 3PX
Citazione:
M. Sullivan et al., "Orchestrating anaphase and mitotic exit: separase cleavage and localization of Slk19", NAT CELL BI, 3(9), 2001, pp. 771-777

Abstract

Anaphase in budding yeast is triggered by cleavage of the central subunit,Sccl, of the chromosomal cohesin complex by the protease separase. Here weshow that separase also cleaves the kinetochore-associated protein Slk19 at anaphase onset. Separase activity is also required for the proper localization of a stable Slk19 cleavage product to the spindle midzone in anaphase. The cleavage and localization of Slk19 are necessary to stabilize the anaphase spindle, and we show that a stable spindle is a prerequisite for timely exit from mitosis This demonstrates the cleavage of targets other than cohesin by separase in the orchestration of high-fidelity anaphase.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 06:35:20