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Titolo:
Antioxidative and antimutagenic activity of yeast cell wall mannans in vitro
Autore:
Krizkova, L; Durackova, Z; Sandula, J; Sasinkova, V; Krajcovic, J;
Indirizzi:
Comenius Univ, Fac Nat Sci, Inst Cell Biol, Bratislava 81107, Slovakia Comenius Univ Bratislava Slovakia 81107 Biol, Bratislava 81107, Slovakia Comenius Univ, Fac Med, Dept Med Chem Biochem & Clin Biochem, Bratislava 81372, Slovakia Comenius Univ Bratislava Slovakia 81372 chem, Bratislava 81372, Slovakia Slovak Acad Sci, Inst Chem, Bratislava 84238, Slovakia Slovak Acad Sci Bratislava Slovakia 84238 em, Bratislava 84238, Slovakia
Titolo Testata:
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
fascicolo: 1-2, volume: 497, anno: 2001,
pagine: 213 - 222
SICI:
1383-5718(20011018)497:1-2<213:AAAAOY>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
EUGLENA-GRACILIS; INDUCED MUTAGENICITY; POLYSACCHARIDE; GLUCOMANNAN; GLUCAN;
Keywords:
yeast cell wall mannans; Candida utilis; Candida albicans; Saccharomyces cerevisiae; Euglena gracilis; ofloxacin; acridine orange; antioxidant; antimutagenicity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Krizkova, L Comenius Univ, Fac Nat Sci, Inst Cell Biol, Odborarske Namestie 5, Bratislava 81107, Slovakia Comenius Univ Odborarske Namestie 5 Bratislava Slovakia 81107
Citazione:
L. Krizkova et al., "Antioxidative and antimutagenic activity of yeast cell wall mannans in vitro", MUT RES-GTE, 497(1-2), 2001, pp. 213-222

Abstract

Antioxidative and antimutagenic effect of yeast cell wall mannans, in particular, extracellular glucomannan (EC-GM) and glucomannan (GM-C.u.) both from Candida utilis, mannan from Saccharomyces cerevisiae (M-S.c.) and mannanfrom Candida albicans (M-C.a.) was evaluated. Luminol-dependent photochemical method using trolox as a standard showed that EC-GM, GM-C.u., M-S.c. and M-C.a. have relatively good antioxidative properties. EC-GM exhibited thehighest antioxidative activity, followed by GM-C.u. and M-S.c. M-C.a. showed the least antioxidative activity. These mannans were experimentally confirmed to exhibit different, statistically significant antimutagenic activity in reducing damage of chloroplast DNA of the flagellate Euglena gracilis induced by ofloxacin and acridine orange (AO). We suggest that the antimutagenic effect of EC-GM, GM-C.u., M-S.c. and M-C.a. against ofloxacin is based on their ability to scavenge reactive oxygen radicals. With AO, the reduction of the chloroplast DNA lession could be a result of the absorptive capacity of the mannans. The important characteristics of mannans isolated from the yeast cell walls, such as good water solubility, relatively small molecular weight (15-30 kDa), and antimutagenic effect exerted through different mode of action, appear to be a promising features for their prospective use as a natural protective (antimutagenic) agents. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 11:58:17