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Titolo:
Genotoxic evaluation of the furylethylene derivative 2-furyl-1-nitroethenein cultured human lymphocytes
Autore:
Borroto, JIG; Creus, A; Marcos, R;
Indirizzi:
Univ Autonoma Barcelona, Fac Ciencies, Dept Genet & Microbiol, Grp Mutagenesi, E-08193 Barcelona, Spain Univ Autonoma Barcelona Barcelona Spain E-08193 E-08193 Barcelona, Spain
Titolo Testata:
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
fascicolo: 1-2, volume: 497, anno: 2001,
pagine: 177 - 184
SICI:
1383-5718(20011018)497:1-2<177:GEOTFD>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
STRUCTURE-MUTAGENICITY RELATIONSHIPS; SALMONELLA-TYPHIMURIUM; MICRONUCLEUS ASSAY; NITROFURANS;
Keywords:
nitrofurans; 2-furyl-1-nitroethene; human lymphocytes; micronuclei; sister-chromatid exchanges;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Marcos, R Univ Autonoma Barcelona, Fac Ciencies, Dept Genet & Microbiol, Grp Mutagenesi, E-08193 Barcelona, Spain Univ Autonoma Barcelona BarcelonaSpain E-08193 rcelona, Spain
Citazione:
J.I.G. Borroto et al., "Genotoxic evaluation of the furylethylene derivative 2-furyl-1-nitroethenein cultured human lymphocytes", MUT RES-GTE, 497(1-2), 2001, pp. 177-184

Abstract

The compound 2-furyl-1-nitroethene (G-0) was evaluated for genotoxicity incultured human peripheral blood lymphocytes, at concentrations ranging from 1 to 15 mug/ml. Micronuclei (MN) and sister-chromatid exchanges (SCEs) were scored as genetic endpoints. In order to detect the role of metabolic enzymes on the genotoxicity of this furylethylenic derivative, the cultures for MN and SCE demonstrations were also treated with S9 microsomal fraction. The results indicate that, under the conditions of the study, the test agent does not seem to induce significant increases in the frequency of micronucleated cells, irrespective of the presence of metabolic activation. Nevertheless, a slight increase in the SCE frequency was observed in those cultures treated without the S9 mix; although this increase disappeared in presence of the microsomal fraction. In addition, cytostatic effects of 2-furyl-1-nitroethene were observed mainly in cultures without S9 fraction, as indicated by the reduction of cell proliferation. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 00:17:52