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Titolo:
Mutagenic and cytotoxic effectiveness of zinc dimethyl and zinc diisononyldithiocarbamate in human lymphocyte cultures
Autore:
Zenzen, V; Fauth, E; Zankl, H; Janzowski, C; Eisenbrand, G;
Indirizzi:
Univ Kaiserslautern, Dept Human Biol & Genet, D-67653 Kaiserslautern, Germany Univ Kaiserslautern Kaiserslautern Germany D-67653 iserslautern, Germany Univ Kaiserslautern, Div Food Chem & Environm Toxicol, D-67653 Kaiserslautern, Germany Univ Kaiserslautern Kaiserslautern Germany D-67653 iserslautern, Germany
Titolo Testata:
MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
fascicolo: 1-2, volume: 497, anno: 2001,
pagine: 89 - 99
SICI:
1383-5718(20011018)497:1-2<89:MACEOZ>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
SISTER-CHROMATID EXCHANGES; CHROMOSOMAL-ABERRATIONS; PERIPHERAL LYMPHOCYTES; MICRONUCLEUS ASSAY; MITOMYCIN-C; GENOTOXICITY; VARIABILITY; AGE; CYCLOPHOSPHAMIDE; LOCALIZATION;
Keywords:
chromosomal aberrations; dithiocarbamates; human lymphocytes; metabolic activation; micronuclei; sister chromatid exchanges;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Zenzen, V Univ Kaiserslautern, Dept Human Biol & Genet, POB 3049, D-67653 Kaiserslautern, Germany Univ Kaiserslautern POB 3049 Kaiserslautern Germany D-67653 any
Citazione:
V. Zenzen et al., "Mutagenic and cytotoxic effectiveness of zinc dimethyl and zinc diisononyldithiocarbamate in human lymphocyte cultures", MUT RES-GTE, 497(1-2), 2001, pp. 89-99

Abstract

The mutagenic and cytotoxic effectiveness of the vulcanisation accelerators zinc dimethyldithiocarbamate (ZDMC; ziram) and zinc diisononyldithiocarbamate (ZDINDC; arbestab Z) was tested in lymphocyte cultures of five healthyprobands. ZDMC and ZDINDC (c = 0.1, 1.0 and 10.0 mug/ml) were studied in lymphocyte cultures without external metabolic activation. Additionally, incubation ofthe compounds (c = 10.0 mug/ml) was performed in the presence of liver microsomes from aroclor-induced rats (1 and 2 h, 1 and 2 mg microsomal protein). Genotoxicity testing was performed by analysis of chromosomal aberrations (CA), sister chromatid exchanges (SCEs) and micronuclei (MN). For evaluation of antiproliferative effects, mitotic index (MI) and cell cycle kinetics (CCK) were determined. In contrast to earlier investigations we found no significantly increased mutagenic or cytotoxic activity of ZDMC; ZDINDC also was inactive under these conditions. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/05/20 alle ore 15:07:20