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Titolo:
Family of SRY/Sox proteins is involved in the regulation of the mouse Msh4(MutS Homolog 4) gene expression
Autore:
Santucci-Darmanin, S; Vidal, F; Scimeca, JC; Turc-Carel, C; Paquis-Flucklinger, V;
Indirizzi:
Fac Med Nice, UMR CNRS UNSA 6549, F-06107 Nice 2, France Fac Med Nice Nice France 2 e, UMR CNRS UNSA 6549, F-06107 Nice 2, France Fac Sci, INSERM, U470, Nice, France Fac Sci Nice FranceFac Sci, INSERM, U470, Nice, France
Titolo Testata:
MOLECULAR REPRODUCTION AND DEVELOPMENT
fascicolo: 2, volume: 60, anno: 2001,
pagine: 172 - 180
SICI:
1040-452X(200110)60:2<172:FOSPII>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
DNA MISMATCH REPAIR; CROSSING-OVER; FEMALE MICE; SRY; BINDING; MEIOSIS; TESTIS; CELLS; SPERMATOGENESIS; CHROMOSOMES;
Keywords:
gametogenesis; gene regulation; meiosis; testis; spermatogenesis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Paquis-Flucklinger, V Fac Med Nice, UMR CNRS UNSA 6549, Av Valombrose, F-06107 Nice 2, France Fac Med Nice Av Valombrose Nice France 2 2, France
Citazione:
S. Santucci-Darmanin et al., "Family of SRY/Sox proteins is involved in the regulation of the mouse Msh4(MutS Homolog 4) gene expression", MOL REPROD, 60(2), 2001, pp. 172-180

Abstract

The eukaryotic MutHLS-like system plays a crucial role in both mitosis andmeiosis. Until now, a number of works have focused on the function of MutSand MutL homologs during mismatch DNA repair. Nevertheless, little is known about the role of these proteins during meiosis. MSH4 is a meiosis specific protein that is necessary for meiotic recombination in Saccharomyces cerevisiae. The human MSH4 protein is only found in testis and ovary. It is involved first in synapsis and second during recombination together with MLH1(MutL Homolog 1). Here, we report the identification of the mouse Msh4 gene that is located on chromosome 3. We examined the expression of mMsh4 in testes of increasing developmental age and in elutriated germ cells. The pattern of expression during spermatogenesis is consistent with a role for MSH4 both during zygonema and pachynema. We demonstrated a promoter activity of the mMsh4 5'-flanking region by cell transfection experiments with a luciferase reporter gene. We found several SRY/Sox binding sites in this regionand co-transfection experiments showed that SRY could down regulate mMsh4 promoter transcriptional activity. We propose that the regulation of mMsh4 expression could be one of the reasons for the persistence of SRY and/or SRY-related proteins in adult testis. Mol. Reprod. Dev. 60: 172-180, 2001, (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 11:02:07