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Titolo:
Calreticulin, a calcium-binding molecular chaperone, is required for stress response and fertility in Caenorhabditis elegans
Autore:
Park, BJ; Lee, DG; Yu, JR; Jung, SK; Choi, K; Lee, J; Lee, J; Kim, YS; Il Lee, J; Kwon, JY; Lee, J; Singson, A; Song, WK; Eom, SH; Park, CS; Kim, DH; Bandyopadhyay, J; Ahnn, J;
Indirizzi:
Kwangju Inst Sci & Technol, Dept Life Sci, Kwangju 500712, South Korea Kwangju Inst Sci & Technol Kwangju South Korea 500712 00712, South Korea Rutgers State Univ, Waksman Inst, Piscataway, NJ 08854 USA Rutgers State Univ Piscataway NJ USA 08854 Inst, Piscataway, NJ 08854 USA Yonsei Univ, Dept Biol, Seoul 120749, South Korea Yonsei Univ Seoul South Korea 120749 ept Biol, Seoul 120749, South Korea Kon Kuk Univ, Coll Med, Dept Parasitol, Chungju 380710, South Korea Kon Kuk Univ Chungju South Korea 380710 tol, Chungju 380710, South Korea
Titolo Testata:
MOLECULAR BIOLOGY OF THE CELL
fascicolo: 9, volume: 12, anno: 2001,
pagine: 2835 - 2845
SICI:
1059-1524(200109)12:9<2835:CACMCI>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOPLASMIC-RETICULUM; SARCOPLASMIC-RETICULUM; GENE FAMILY; PROTEIN; EXPRESSION; RECEPTOR; CELL; SPERM; CALNEXIN; MEMBRANE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Ahnn, J Kwangju Inst Sci & Technol, Dept Life Sci, Kwangju 500712, South Korea Kwangju Inst Sci & Technol Kwangju South Korea 500712 outh Korea
Citazione:
B.J. Park et al., "Calreticulin, a calcium-binding molecular chaperone, is required for stress response and fertility in Caenorhabditis elegans", MOL BIOL CE, 12(9), 2001, pp. 2835-2845

Abstract

Calreticulin (CRT), a Ca2+-binding protein known to have many cellular functions, including regulation of Ca2+ homoeostasis and chaperone activity, is essential for heart and brain development during embryogenesis in mice. Here, we report the functional characterization of Caenorhabditis elegans calreticulin (crt-1). A crt-1 null mutant does not result in embryonic lethality but shows temperature-dependent reproduction defects. In C. elegans CRT-1 is expressed in the intestine, pharynx, body-wall muscles, head neurons,coelomocytes, and in sperm. crt-1 males exhibit reduced mating efficiency and defects late in sperm development in addition to defects in oocyte development and/or somatic gonad function in hermaphrodites. Furthermore, crt-1and itr-1 (inositol triphosphate receptor) together are required for normal behavioral rhythms. crt-1 transcript level is elevated under stress conditions, suggesting that CRT-1 may be important for stress-induced chaperoning function in C. elegans.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 07:47:11