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Titolo:
The domain structure of centromeres is conserved from fission yeast to humans
Autore:
Kniola, B; OToole, E; McIntosh, JR; Mellone, B; Allshire, R; Mengarelli, S; Hultenby, K; Ekwall, K;
Indirizzi:
Univ Coll Sodertorn, Dept Nat Sci, Novum, Dept Biosci,Karolinska Inst, S-14104 Huddinge, Sweden Univ Coll Sodertorn Huddinge Sweden S-14104 st, S-14104 Huddinge, Sweden Univ Colorado, Lab Fine Struct 3D, Boulder, CO 80309 USA Univ Colorado Boulder CO USA 80309 Fine Struct 3D, Boulder, CO 80309 USA MRC, Human Genet Unit, Edinburgh EH4 2XU, Midlothian, Scotland MRC Edinburgh Midlothian Scotland EH4 2XU h EH4 2XU, Midlothian, Scotland Huddinge Sjukhus, Clin Res Ctr, Microscopy Unit, S-14186 Huddinge, Sweden Huddinge Sjukhus Huddinge Sweden S-14186 Unit, S-14186 Huddinge, Sweden
Titolo Testata:
MOLECULAR BIOLOGY OF THE CELL
fascicolo: 9, volume: 12, anno: 2001,
pagine: 2767 - 2775
SICI:
1059-1524(200109)12:9<2767:TDSOCI>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
INNER KINETOCHORE PLATE; SPINDLE POLE BODY; CENP-A; SCHIZOSACCHAROMYCES-POMBE; CHROMOSOME SEGREGATION; MAMMALIAN-CELLS; PROTEIN; COMPONENT; LOCALIZATION; SCLERODERMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Ekwall, K Univ Coll Sodertorn, Dept Nat Sci, Novum, Dept Biosci,KarolinskaInst, S-14104 Huddinge, Sweden Univ Coll Sodertorn Huddinge Sweden S-14104 4 Huddinge, Sweden
Citazione:
B. Kniola et al., "The domain structure of centromeres is conserved from fission yeast to humans", MOL BIOL CE, 12(9), 2001, pp. 2767-2775

Abstract

The centromeric DNA of fission yeast is arranged with a central core flanked by repeated sequences. The centromere-associated proteins, Mis6p and Cnp1p (SpCENP-A), associate exclusively with central core DNA, whereas the Swi6 protein binds the surrounding repeats. Here, electron microscopy and immunofluorescence light microscopy reveal that the central core and flanking regions occupy distinct positions within a heterochromatic domain. An "anchor" structure containing the Ndc80 protein resides between this heterochromatic domain and the spindle pole body. The organization of centromere-associated proteins in fission yeast is reminiscent of the multilayered structures of human kinetochores, indicating that such domain structure is conservedin eukaryotes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/21 alle ore 04:43:57